USP13
UniProt ID: Q92995
Entrez ID: 8975
Protein name: Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: m...
FUNCTION: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data. {ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647, ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260, ECO:0000269|PubMed:24424410}.
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GO - Biological processes (BP):
autophagy [GO:0006914]; cell population proliferation [GO:0008283]; maintenance of unfolded protein involved in ERAD pathway [GO:1904378]; melanocyte differentiation [GO:0030318]; positive regulation of ERAD pathway [GO:1904294]; protein deubiquitination [GO:0016579]; protein K29-linked deubiquitina...
autophagy [GO:0006914]; cell population proliferation [GO:0008283]; maintenance of unfolded protein involved in ERAD pathway [GO:1904378]; melanocyte differentiation [GO:0030318]; positive regulation of ERAD pathway [GO:1904294]; protein deubiquitination [GO:0016579]; protein K29-linked deubiquitination [GO:0035523]; protein K63-linked deubiquitination [GO:0070536]; protein K6-linked deubiquitination [GO:0044313]; protein stabilization [GO:0050821]; regulation of autophagy [GO:0010506]; regulation of transcription, DNA-templated [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]
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GO - Molecular function (MF):
BAT3 complex binding [GO:1904288]; chaperone binding [GO:0051087]; cysteine-type endopeptidase activity [GO:0004197]; Lys48-specific deubiquitinase activity [GO:1990380]; proteasome binding [GO:0070628]; thiol-dependent deubiquitinase [GO:0004843]; ubiquitin binding [GO:0043130]; ubiquitin-like prot...
BAT3 complex binding [GO:1904288]; chaperone binding [GO:0051087]; cysteine-type endopeptidase activity [GO:0004197]; Lys48-specific deubiquitinase activity [GO:1990380]; proteasome binding [GO:0070628]; thiol-dependent deubiquitinase [GO:0004843]; ubiquitin binding [GO:0043130]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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USP13
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*NOTE: the Kaplan plots were collected from OncoLnc