DegronMD

Uniprot ID: Q92995

Source protein: Ubiquitin carboxyl-terminal hydrolase 13

Source gene: USP13

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9352

ASA_SCORE: 81.1778

COIL: 0.7964

CONS_SCORE: 0.1235

DSS_SCORE: 0.7214

HELIX: 0.0977

FCONS_SCORE: 0.8478

RIG_SCORE: 0.696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G13S	TCGA-04-1638	OV	TCGA	RRGALFGMP	DEG_APCC_DBOX_1	0.2778
p.G13S	DO28701	OV	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.2778
p.Q2K	TCGA-EO-A22Y	UCEC	TCGA	RRGALFGMP	DEG_APCC_DBOX_1	0.3056
p.Q2K	DO43570	UCEC	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.3056
p.E10K	DO49976	CESC	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.7022
p.N2Y	DO228198	LICA	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.3056
p.G13V	DO229006	LICA	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.2778
p.A6S	DO23768	LUAD	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.6477
p.K18T	DO36556	READ	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.5833
p.R17Q	DO40884	UCEC	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.1667
p.R17Q	DO41020	UCEC	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.1667
p.R17Q	DO41379	UCEC	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.1667
p.L5S	DO52402	UCEC	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.7667
p.N2H	DO41133	UCEC	ICGC	RRGALFGMP	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92995	Ubiquitin carboxyl-terminal hydrolase 13	DEG_APCC_DBOX_1	3:11	RRGALFGMP	APC,CDC20,FZR1	0.9352	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons