DegronMD - Q969E3(UCN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R63C	TCGA-AJ-A3EK	UCEC	TCGA	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.25
p.R63C	DO41584	UCEC	ICGC	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.25
p.R63C	SIDM00217	Colorectal Carcinoma	GDSC	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.25
p.R63C	ACH-000999	Colon/Colorectal Cancer	CCLE	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.25
p.R63C	SNU-1040	large intestine	COSMIC	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.25
p.T80I	TCGA-AP-A059	UCEC	TCGA	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.0833
p.T80I	DO41361	UCEC	ICGC	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.0833
p.F59S	TCGA-EB-A431	SKCM	TCGA	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.1389
p.F59S	DO37671	SKCM	ICGC	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.1389
p.K56E	DO228893	LICA	ICGC	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation substituting flanking lysine	0.1667
p.R63P	SIDM01646	Non-Cancerous	GDSC	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.25
p.R63P	ACH-002358	Non-Cancerous	CCLE	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation rewiring degron network	0.25
p.D66N	ACH-000221	Liver Cancer	CCLE	DASSGE	DEG_Kelch_Keap1_1	66:71	Mutation altering degron motif	0.5821

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons