DegronMD

Uniprot ID: Q969E3

Source protein: Urocortin-3

Source gene: UCN3

Class: DEG_Kelch_Keap1_1

Location: 66:71

E3 ligase: KEAP1

DEGRON score: 0.9648

ASA_SCORE: 78

COIL: 0.8895

CONS_SCORE: 0.6047

DSS_SCORE: 0.5198

HELIX: 0.0868

FCONS_SCORE: 1.1154

RIG_SCORE: 0.5837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R63C	TCGA-AJ-A3EK	UCEC	TCGA	DASSGE	DEG_Kelch_Keap1_1	0.25
p.R63C	DO41584	UCEC	ICGC	DASSGE	DEG_Kelch_Keap1_1	0.25
p.R63C	SIDM00217	Colorectal Carcinoma	GDSC	DASSGE	DEG_Kelch_Keap1_1	0.25
p.R63C	ACH-000999	Colon/Colorectal Cancer	CCLE	DASSGE	DEG_Kelch_Keap1_1	0.25
p.R63C	SNU-1040	large_intestine	COSMIC	DASSGE	DEG_Kelch_Keap1_1	0.25
p.T80I	TCGA-AP-A059	UCEC	TCGA	DASSGE	DEG_Kelch_Keap1_1	0.0833
p.T80I	DO41361	UCEC	ICGC	DASSGE	DEG_Kelch_Keap1_1	0.0833
p.F59S	TCGA-EB-A431	SKCM	TCGA	DASSGE	DEG_Kelch_Keap1_1	0.1389
p.F59S	DO37671	SKCM	ICGC	DASSGE	DEG_Kelch_Keap1_1	0.1389
p.K56E	DO228893	LICA	ICGC	DASSGE	DEG_Kelch_Keap1_1	0.1667
p.R63P	SIDM01646	Non-Cancerous	GDSC	DASSGE	DEG_Kelch_Keap1_1	0.25
p.R63P	ACH-002358	Non-Cancerous	CCLE	DASSGE	DEG_Kelch_Keap1_1	0.25
p.D66N	ACH-000221	Liver Cancer	CCLE	DASSGE	DEG_Kelch_Keap1_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969E3	Urocortin-3	DEG_Kelch_Keap1_1	66:71	DASSGE	KEAP1	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons