DegronMD - Q969G9(NKD1)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V439L	TCGA-17-Z050	LUAD	TCGA	GREHLRELP	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.25
p.A437T	TCGA-85-8048	LUSC	TCGA	GREHLRELP	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.3056
p.A437T	DO27389	LUSC	ICGC	GREHLRELP	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.3056
p.A437T	SIDM00602	Gastric Carcinoma	GDSC	GREHLRELP	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.3056
p.A437T	ACH-000919	Gastric Cancer	CCLE	GREHLRELP	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.3056
p.R429W	TCGA-ND-A4WC	UCS	TCGA	GREHLRELP	DEG_APCC_DBOX_1	428:436	Mutation altering degron motif	0.8634
p.A418T	DO233088	GACA	ICGC	GREHLRELP	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.0556
p.R429Q	DO233732	GACA	ICGC	GREHLRELP	DEG_APCC_DBOX_1	428:436	Mutation altering degron motif	0.7329
p.E442G	ACH-000982	Colon/Colorectal Cancer	CCLE	GREHLRELP	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.1667
p.S443N	ACH-001982	Metastasis	CCLE	GREHLRELP	DEG_APCC_DBOX_1	428:436	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons