DegronMD

Uniprot ID: Q969G9

Source protein: Protein naked cuticle homolog 1

Source gene: NKD1

Class: DEG_APCC_DBOX_1

Location: 428:436

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8314

ASA_SCORE: 81.4889

COIL: 0.639

CONS_SCORE: 0.4588

DSS_SCORE: 0.415

HELIX: 0.3069

FCONS_SCORE: 1.3001

RIG_SCORE: 0.7534

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V439L	TCGA-17-Z050	LUAD	TCGA	GREHLRELP	DEG_APCC_DBOX_1	0.25
p.A437T	TCGA-85-8048	LUSC	TCGA	GREHLRELP	DEG_APCC_DBOX_1	0.3056
p.A437T	DO27389	LUSC	ICGC	GREHLRELP	DEG_APCC_DBOX_1	0.3056
p.A437T	SIDM00602	Gastric Carcinoma	GDSC	GREHLRELP	DEG_APCC_DBOX_1	0.3056
p.A437T	ACH-000919	Gastric Cancer	CCLE	GREHLRELP	DEG_APCC_DBOX_1	0.3056
p.R429W	TCGA-ND-A4WC	UCS	TCGA	GREHLRELP	DEG_APCC_DBOX_1	0.8634
p.A418T	DO233088	GACA	ICGC	GREHLRELP	DEG_APCC_DBOX_1	0.0556
p.R429Q	DO233732	GACA	ICGC	GREHLRELP	DEG_APCC_DBOX_1	0.7329
p.E442G	ACH-000982	Colon/Colorectal Cancer	CCLE	GREHLRELP	DEG_APCC_DBOX_1	0.1667
p.S443N	ACH-001982	Metastasis	CCLE	GREHLRELP	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969G9	Protein naked cuticle homolog 1	DEG_APCC_DBOX_1	428:436	GREHLRELP	APC,CDC20,FZR1	0.8314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons