DegronMD - Q969H4(CNKSR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P280L	TCGA-AJ-A3OK	UCEC	TCGA	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.1667
p.P294Q	TCGA-AP-A051	UCEC	TCGA	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.3056
p.P278Q	TCGA-BQ-7053	KIRP	TCGA	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation blocking phosphorylation signal	0.5556
p.P278Q	TCGA-EE-A29E	SKCM	TCGA	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation blocking phosphorylation signal	0.5556
p.P278Q	DO20946	KIRP	ICGC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation blocking phosphorylation signal	0.5556
p.P278Q	DO37831	SKCM	ICGC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation blocking phosphorylation signal	0.5556
p.E281D	TCGA-FI-A2D5	UCEC	TCGA	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.1944
p.E281D	ACH-001819	Breast Cancer	CCLE	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.1944
p.E288D	DO228207	LICA	ICGC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.5647
p.E288D	DO41331	UCEC	ICGC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.5647
p.S300F	DO229177	LMS	ICGC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation blocking phosphorylation signal	0.5833
p.S300F	SIDM01575	Plasma Cell Myeloma	GDSC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation blocking phosphorylation signal	0.5833
p.P287L	DO43602	UCEC	ICGC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.6471
p.P301Q	DO42673	UCEC	ICGC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.1111
p.T293M	SIDM00040	Gastric Carcinoma	GDSC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.8534
p.T293M	TMK-1	stomach	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.8534
p.S278G	SIDM00333	Endometrial Carcinoma	GDSC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation blocking phosphorylation signal	0.5556
p.S278G	MFE-319	endometrium	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation blocking phosphorylation signal	0.5556
p.P291Q	SIDM00316	Glioblastoma	GDSC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.5924
p.P291Q	YH-13	central nervous system	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.5924
p.S293F	ACH-000426	Myeloma	CCLE	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.7982
p.T286M	TMK-1	stomach	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.7423
p.R295H	TGBC11TKB	stomach	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.2778
p.P284Q	YH-13	central nervous system	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.2778
p.R298Q	NB-4	haematopoietic and lymphoid tissue	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.1944

Kaplan plot for CNKSR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNKSR1

UniProt ID: Q969H4

Entrez ID: 10256

Protein name: Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNKSR1 in