DegronMD

Uniprot ID: Q969H4

Source protein: Connector enhancer of kinase suppressor of ras 1

Source gene: CNKSR1

Class: DEG_SCF_FBW7_1

Location: 286:293

E3 ligase: FBXW7

DEGRON score: 0.9741

ASA_SCORE: 94.4125

COIL: 0.9486

CONS_SCORE: 0.4102

DSS_SCORE: 0.634

HELIX: 0.0131

FCONS_SCORE: 0.8906

RIG_SCORE: 0.6153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P280L	TCGA-AJ-A3OK	UCEC	TCGA	IPETPPQT	DEG_SCF_FBW7_1	0.1667
p.P294Q	TCGA-AP-A051	UCEC	TCGA	IPETPPQT	DEG_SCF_FBW7_1	0.3056
p.P278Q	TCGA-BQ-7053	KIRP	TCGA	IPETPPQT	DEG_SCF_FBW7_1	0.5556
p.P278Q	TCGA-EE-A29E	SKCM	TCGA	IPETPPQT	DEG_SCF_FBW7_1	0.5556
p.P278Q	DO20946	KIRP	ICGC	IPETPPQT	DEG_SCF_FBW7_1	0.5556
p.P278Q	DO37831	SKCM	ICGC	IPETPPQT	DEG_SCF_FBW7_1	0.5556
p.E281D	TCGA-FI-A2D5	UCEC	TCGA	IPETPPQT	DEG_SCF_FBW7_1	0.1944
p.E281D	ACH-001819	Breast Cancer	CCLE	IPETPPQT	DEG_SCF_FBW7_1	0.1944
p.E288D	DO228207	LICA	ICGC	IPETPPQT	DEG_SCF_FBW7_1	0.5647
p.E288D	DO41331	UCEC	ICGC	IPETPPQT	DEG_SCF_FBW7_1	0.5647
p.S300F	DO229177	LMS	ICGC	IPETPPQT	DEG_SCF_FBW7_1	0.5833
p.S300F	SIDM01575	Plasma Cell Myeloma	GDSC	IPETPPQT	DEG_SCF_FBW7_1	0.5833
p.P287L	DO43602	UCEC	ICGC	IPETPPQT	DEG_SCF_FBW7_1	0.6471
p.P301Q	DO42673	UCEC	ICGC	IPETPPQT	DEG_SCF_FBW7_1	0.1111
p.T293M	SIDM00040	Gastric Carcinoma	GDSC	IPETPPQT	DEG_SCF_FBW7_1	0.8534
p.T293M	TMK-1	stomach	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	0.8534
p.S278G	SIDM00333	Endometrial Carcinoma	GDSC	IPETPPQT	DEG_SCF_FBW7_1	0.5556
p.S278G	MFE-319	endometrium	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	0.5556
p.P291Q	SIDM00316	Glioblastoma	GDSC	IPETPPQT	DEG_SCF_FBW7_1	0.5924
p.P291Q	YH-13	central_nervous_system	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	0.5924
p.S293F	ACH-000426	Myeloma	CCLE	IPETPPQT	DEG_SCF_FBW7_1	0.7982
p.T286M	TMK-1	stomach	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	0.7423
p.R295H	TGBC11TKB	stomach	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	0.2778
p.P284Q	YH-13	central_nervous_system	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	0.2778
p.R298Q	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	IPETPPQT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969H4	Connector enhancer of kinase suppressor of ras 1	DEG_SCF_FBW7_1	286:293	IPETPPQT	FBXW7	0.9741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPETPPQT

Degron related mutations and impact score

Drug responses associated with CNKSR1 mutations

All proteins holding degron of IPETPPQT