DegronMD - Q969M2(GJA10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G448E	TCGA-18-3409	LUSC	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation altering degron motif	0.7199
p.G448E	TCGA-WE-AAA3	SKCM	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation altering degron motif	0.7199
p.G448E	DO26444	LUSC	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation altering degron motif	0.7199
p.G448E	DO51295	SKCM	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation altering degron motif	0.7199
p.R441Q	TCGA-AA-3510	COAD	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1944
p.R441Q	TCGA-EE-A181	SKCM	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1944
p.R441Q	TCGA-EO-A22R	UCEC	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1944
p.R441Q	DO7783	COAD	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1944
p.R441Q	DO37444	SKCM	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1944
p.R441Q	DO42713	UCEC	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1944
p.S455I	TCGA-AJ-A3EK	UCEC	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.25
p.S455I	DO41584	UCEC	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.25
p.D459G	TCGA-AP-A056	UCEC	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1389
p.D459G	DO43971	UCEC	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1389
p.P461S	TCGA-EE-A29E	SKCM	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.0833
p.P461S	TCGA-GN-A8LK	SKCM	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.0833
p.P461S	DO37831	SKCM	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.0833
p.P461S	DO51259	SKCM	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.0833
p.R453Q	TCGA-EE-A2GC	SKCM	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.3056
p.R453Q	DO37839	SKCM	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.3056
p.K440M	TCGA-KQ-A41N	BLCA	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation substituting flanking lysine	0.2778
p.K440M	DO223588	BLCA	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation substituting flanking lysine	0.2778
p.R453W	DO228650	LICA	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.3056
p.L437F	DO229031	LICA	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.0833
p.D459N	SIDM00007	Other Solid Cancers	GDSC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1389
p.D459N	ACH-001550	Skin Cancer	CCLE	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1389
p.D459N	MCC13	skin	COSMIC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1389
p.E439K	SIDM00995	Other Solid Cancers	GDSC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1389
p.E439K	ACH-001328	Skin Cancer	CCLE	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1389
p.E439K	A431	skin	COSMIC	DSGSSGS	DEG_SCF_TRCP1_1	446:452	Mutation rewiring degron network	0.1389

Kaplan plot for GJA10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GJA10

UniProt ID: Q969M2

Entrez ID: 84694

Protein name: Gap junction alpha-10 protein (Connexin-62) (Cx62)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GJA10 in