DegronMD

Uniprot ID: Q969M2

Source protein: Gap junction alpha-10 protein

Source gene: GJA10

Class: DEG_SCF_TRCP1_1

Location: 446:452

E3 ligase: BTRC

DEGRON score: 0.6719

ASA_SCORE: 70.2429

COIL: 0.9143

CONS_SCORE: 0.5082

DSS_SCORE: 0.5033

HELIX: 0.0587

FCONS_SCORE: 1.1196

RIG_SCORE: 0.4937

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G448E	TCGA-18-3409	LUSC	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.7199
p.G448E	TCGA-WE-AAA3	SKCM	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.7199
p.G448E	DO26444	LUSC	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.7199
p.G448E	DO51295	SKCM	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.7199
p.R441Q	TCGA-AA-3510	COAD	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.1944
p.R441Q	TCGA-EE-A181	SKCM	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.1944
p.R441Q	TCGA-EO-A22R	UCEC	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.1944
p.R441Q	DO7783	COAD	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.1944
p.R441Q	DO37444	SKCM	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.1944
p.R441Q	DO42713	UCEC	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.1944
p.S455I	TCGA-AJ-A3EK	UCEC	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.25
p.S455I	DO41584	UCEC	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.25
p.D459G	TCGA-AP-A056	UCEC	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.1389
p.D459G	DO43971	UCEC	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.1389
p.P461S	TCGA-EE-A29E	SKCM	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.0833
p.P461S	TCGA-GN-A8LK	SKCM	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.0833
p.P461S	DO37831	SKCM	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.0833
p.P461S	DO51259	SKCM	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.0833
p.R453Q	TCGA-EE-A2GC	SKCM	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.3056
p.R453Q	DO37839	SKCM	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.3056
p.K440M	TCGA-KQ-A41N	BLCA	TCGA	DSGSSGS	DEG_SCF_TRCP1_1	0.2778
p.K440M	DO223588	BLCA	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.2778
p.R453W	DO228650	LICA	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.3056
p.L437F	DO229031	LICA	ICGC	DSGSSGS	DEG_SCF_TRCP1_1	0.0833
p.D459N	SIDM00007	Other Solid Cancers	GDSC	DSGSSGS	DEG_SCF_TRCP1_1	0.1389
p.D459N	ACH-001550	Skin Cancer	CCLE	DSGSSGS	DEG_SCF_TRCP1_1	0.1389
p.D459N	MCC13	skin	COSMIC	DSGSSGS	DEG_SCF_TRCP1_1	0.1389
p.E439K	SIDM00995	Other Solid Cancers	GDSC	DSGSSGS	DEG_SCF_TRCP1_1	0.1389
p.E439K	ACH-001328	Skin Cancer	CCLE	DSGSSGS	DEG_SCF_TRCP1_1	0.1389
p.E439K	A431	skin	COSMIC	DSGSSGS	DEG_SCF_TRCP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSSGS

Degron related mutations and impact score

Drug responses associated with GJA10 mutations

All proteins holding degron of DSGSSGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969M2	Gap junction alpha-10 protein	DEG_SCF_TRCP1_1	446:452	DSGSSGS	BTRC	0.6719	More...