DegronMD - Q969R2(OSBP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T450A	TCGA-19-5956	GBM	TCGA	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation rewiring degron network	0.1111
p.T450A	DO13863	GBM	ICGC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation rewiring degron network	0.1111
p.S435R	TCGA-28-1757	GBM	TCGA	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation rewiring degron network	0.3056
p.S435R	DO12166	GBM	ICGC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation rewiring degron network	0.3056
p.Y452H	TCGA-69-8253	LUAD	TCGA	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation rewiring degron network	0.0556
p.Y452H	DO23637	LUAD	ICGC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation rewiring degron network	0.0556
p.L436I	TCGA-A5-A0G1	UCEC	TCGA	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.6063
p.L436I	DO42472	UCEC	ICGC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.6063
p.P439H	TCGA-EE-A181	SKCM	TCGA	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.7694
p.P439H	DO37444	SKCM	ICGC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.7694
p.E442K	TCGA-W3-AA21	SKCM	TCGA	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.7022
p.E442K	DO51278	SKCM	ICGC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.7022
p.E442K	GAK	skin	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.7022
p.P427H	DO229257	THCA	ICGC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation rewiring degron network	0.0833
p.T438I	SIDM00849	Kidney Carcinoma	GDSC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.8189
p.T438I	SIDM00808	Burkitt's Lymphoma	GDSC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.8189
p.T438I	SIDM01254	Burkitt's Lymphoma	GDSC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.8189
p.T438I	A704	kidney	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.8189
p.T438I	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.8189
p.A428T	GP5d	large intestine	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation blocking phosphorylation signal	0.5556
p.E435K	GAK	skin	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation rewiring degron network	0.3056
p.P439S	HCC2998	large intestine	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation altering degron motif	0.6752
p.K445Q	BxPC-3	pancreas	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	436:442	Mutation rewiring degron network	0.25

Kaplan plot for OSBP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OSBP2

UniProt ID: Q969R2

Entrez ID: 23762

Protein name: Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OSBP2 in