DegronMD

Uniprot ID: Q969R2

Source protein: Oxysterol-binding protein 2

Source gene: OSBP2

Class: DEG_SCF_FBW7_2

Location: 436:442

E3 ligase: FBXW7

DEGRON score: 0.9359

ASA_SCORE: 79.4143

COIL: 0.7911

CONS_SCORE: 0.3064

DSS_SCORE: 0.7024

HELIX: 0.063

FCONS_SCORE: 0.9261

RIG_SCORE: 0.6322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T450A	TCGA-19-5956	GBM	TCGA	LLTPKGE	DEG_SCF_FBW7_2	0.1111
p.T450A	DO13863	GBM	ICGC	LLTPKGE	DEG_SCF_FBW7_2	0.1111
p.S435R	TCGA-28-1757	GBM	TCGA	LLTPKGE	DEG_SCF_FBW7_2	0.3056
p.S435R	DO12166	GBM	ICGC	LLTPKGE	DEG_SCF_FBW7_2	0.3056
p.Y452H	TCGA-69-8253	LUAD	TCGA	LLTPKGE	DEG_SCF_FBW7_2	0.0556
p.Y452H	DO23637	LUAD	ICGC	LLTPKGE	DEG_SCF_FBW7_2	0.0556
p.L436I	TCGA-A5-A0G1	UCEC	TCGA	LLTPKGE	DEG_SCF_FBW7_2	0.6063
p.L436I	DO42472	UCEC	ICGC	LLTPKGE	DEG_SCF_FBW7_2	0.6063
p.P439H	TCGA-EE-A181	SKCM	TCGA	LLTPKGE	DEG_SCF_FBW7_2	0.7694
p.P439H	DO37444	SKCM	ICGC	LLTPKGE	DEG_SCF_FBW7_2	0.7694
p.E442K	TCGA-W3-AA21	SKCM	TCGA	LLTPKGE	DEG_SCF_FBW7_2	0.7022
p.E442K	DO51278	SKCM	ICGC	LLTPKGE	DEG_SCF_FBW7_2	0.7022
p.E442K	GAK	skin	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	0.7022
p.P427H	DO229257	THCA	ICGC	LLTPKGE	DEG_SCF_FBW7_2	0.0833
p.T438I	SIDM00849	Kidney Carcinoma	GDSC	LLTPKGE	DEG_SCF_FBW7_2	0.8189
p.T438I	SIDM00808	Burkitt's Lymphoma	GDSC	LLTPKGE	DEG_SCF_FBW7_2	0.8189
p.T438I	SIDM01254	Burkitt's Lymphoma	GDSC	LLTPKGE	DEG_SCF_FBW7_2	0.8189
p.T438I	A704	kidney	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	0.8189
p.T438I	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	0.8189
p.A428T	GP5d	large_intestine	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	0.5556
p.E435K	GAK	skin	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	0.3056
p.P439S	HCC2998	large_intestine	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	0.6752
p.K445Q	BxPC-3	pancreas	COSMIC	LLTPKGE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969R2	Oxysterol-binding protein 2	DEG_SCF_FBW7_2	436:442	LLTPKGE	FBXW7	0.9359	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons