DegronMD - Q969R5(L3MBTL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E2D	TCGA-A5-A0G2	UCEC	TCGA	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation blocking phosphorylation signal	0.6389
p.E2D	DO41235	UCEC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation blocking phosphorylation signal	0.6389
p.M16K	TCGA-AX-A05S	UCEC	TCGA	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.2778
p.M16K	DO43218	UCEC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.2778
p.D23N	TCGA-D1-A15X	UCEC	TCGA	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.0833
p.D23N	DO43274	UCEC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.0833
p.R5Q	TCGA-D3-A8GB	SKCM	TCGA	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.2778
p.R5Q	DO50280	SKCM	ICGC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.2778
p.S6I	TCGA-EO-A22R	UCEC	TCGA	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.3056
p.S6I	DO42713	UCEC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.3056
p.E8K	TCGA-K4-A54R	BLCA	TCGA	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.591
p.E8K	DO48611	BLCA	ICGC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.591
p.E20K	TCGA-RN-A68Q	SARC	TCGA	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.1667
p.E20K	DO220263	SARC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.1667
p.I7V	DO52365	LUSC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00437	Acute Myeloid Leukemia	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00578	Neuroblastoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00615	Hepatocellular Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00234	Other Solid Cancers	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00064	Hepatocellular Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00291	Melanoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00607	Glioblastoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00231	Kidney Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00465	Ovarian Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00394	Cervical Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01196	Hepatocellular Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00301	Pancreatic Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01045	Endometrial Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00383	Gastric Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00585	Hepatocellular Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00294	Small Cell Lung Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00024	Non-Cancerous	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00365	Small Cell Lung Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00567	Other Solid Cancers	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00997	Thyroid Gland Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01061	Oral Cavity Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00655	Other Solid Cancers	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01217	Other Blood Cancers	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00566	Oral Cavity Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM00233	T-Lymphoblastic Leukemia	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01727	Chronic Myelogenous Leukemia	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01608	Endometrial Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01470	Acute Myeloid Leukemia	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01432	Kidney Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01469	Pancreatic Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01343	Gastric Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.I7V	SIDM01619	Endometrial Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5965
p.R5G	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.2778
p.R5G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.2778
p.E8Q	SIDM00767	Small Cell Lung Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5633
p.E8Q	ACH-001136	Lung Cancer	CCLE	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5633
p.E8Q	NCI-H187	lung	COSMIC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation altering degron motif	0.5633
p.D23V	SIDM00083	Glioblastoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.0833
p.D23V	ACH-000273	Brain Cancer	CCLE	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.0833
p.D23V	SF539	central nervous system	COSMIC	IEETPSSE	DEG_SCF_FBW7_2	7:14	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

L3MBTL2

UniProt ID: Q969R5

Entrez ID: 83746

Protein name: Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for L3MBTL2 in