DegronMD

Uniprot ID: Q969R5

Source protein: Lethal

Source gene: L3MBTL2

Class: DEG_SCF_FBW7_2

Location: 7:14

E3 ligase: FBXW7

DEGRON score: 0.6321

ASA_SCORE: 98.85

COIL: 0.7816

CONS_SCORE: 0.429

DSS_SCORE: 0.8959

HELIX: 0.22

FCONS_SCORE: 0.9211

RIG_SCORE: 0.5979

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2D	TCGA-A5-A0G2	UCEC	TCGA	IEETPSSE	DEG_SCF_FBW7_2	0.6389
p.E2D	DO41235	UCEC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	0.6389
p.M16K	TCGA-AX-A05S	UCEC	TCGA	IEETPSSE	DEG_SCF_FBW7_2	0.2778
p.M16K	DO43218	UCEC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	0.2778
p.D23N	TCGA-D1-A15X	UCEC	TCGA	IEETPSSE	DEG_SCF_FBW7_2	0.0833
p.D23N	DO43274	UCEC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	0.0833
p.R5Q	TCGA-D3-A8GB	SKCM	TCGA	IEETPSSE	DEG_SCF_FBW7_2	0.2778
p.R5Q	DO50280	SKCM	ICGC	IEETPSSE	DEG_SCF_FBW7_2	0.2778
p.S6I	TCGA-EO-A22R	UCEC	TCGA	IEETPSSE	DEG_SCF_FBW7_2	0.3056
p.S6I	DO42713	UCEC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	0.3056
p.E8K	TCGA-K4-A54R	BLCA	TCGA	IEETPSSE	DEG_SCF_FBW7_2	0.591
p.E8K	DO48611	BLCA	ICGC	IEETPSSE	DEG_SCF_FBW7_2	0.591
p.E20K	TCGA-RN-A68Q	SARC	TCGA	IEETPSSE	DEG_SCF_FBW7_2	0.1667
p.E20K	DO220263	SARC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	0.1667
p.I7V	DO52365	LUSC	ICGC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00437	Acute Myeloid Leukemia	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00578	Neuroblastoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00615	Hepatocellular Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00234	Other Solid Cancers	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00064	Hepatocellular Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00291	Melanoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00607	Glioblastoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00231	Kidney Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00465	Ovarian Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00394	Cervical Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01196	Hepatocellular Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00301	Pancreatic Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01045	Endometrial Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00383	Gastric Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00585	Hepatocellular Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00294	Small Cell Lung Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00024	Non-Cancerous	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00365	Small Cell Lung Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00567	Other Solid Cancers	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00997	Thyroid Gland Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01061	Oral Cavity Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00655	Other Solid Cancers	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01217	Other Blood Cancers	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00566	Oral Cavity Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM00233	T-Lymphoblastic Leukemia	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01727	Chronic Myelogenous Leukemia	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01608	Endometrial Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01470	Acute Myeloid Leukemia	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01432	Kidney Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01469	Pancreatic Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01343	Gastric Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.I7V	SIDM01619	Endometrial Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5965
p.R5G	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.2778
p.R5G	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IEETPSSE	DEG_SCF_FBW7_2	0.2778
p.E8Q	SIDM00767	Small Cell Lung Carcinoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.5633
p.E8Q	ACH-001136	Lung Cancer	CCLE	IEETPSSE	DEG_SCF_FBW7_2	0.5633
p.E8Q	NCI-H187	lung	COSMIC	IEETPSSE	DEG_SCF_FBW7_2	0.5633
p.D23V	SIDM00083	Glioblastoma	GDSC	IEETPSSE	DEG_SCF_FBW7_2	0.0833
p.D23V	ACH-000273	Brain Cancer	CCLE	IEETPSSE	DEG_SCF_FBW7_2	0.0833
p.D23V	SF539	central_nervous_system	COSMIC	IEETPSSE	DEG_SCF_FBW7_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IEETPSSE

Degron related mutations and impact score

Drug responses associated with L3MBTL2 mutations

All proteins holding degron of IEETPSSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969R5	Lethal	DEG_SCF_FBW7_2	7:14	IEETPSSE	FBXW7	0.6321	More...