DegronMD - Q969T3(SNX21)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L350P	DO222874	COCA	ICGC	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1944
p.E370G	DO232761	PBCA	ICGC	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1111
p.L367F	SIDM00282	Colorectal Carcinoma	GDSC	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1944
p.L367F	CW-2	large intestine	COSMIC	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1944
p.R346Q	SIDM00539	Esophageal Carcinoma	GDSC	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.0833
p.P359T	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation altering degron motif	0.7031
p.P359T	KYSE-270	oesophagus	COSMIC	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation altering degron motif	0.7031
p.P350T	ACH-000873	Esophageal Cancer	CCLE	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1944
p.P350T	KYSE-270	oesophagus	COSMIC	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1944
p.L358F	ACH-000998	Colon/Colorectal Cancer	CCLE	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation altering degron motif	0.6981
p.L358F	CW-2	large intestine	COSMIC	LTPTPPPS	DEG_SCF_FBW7_1	355:362	Mutation altering degron motif	0.6981

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons