DegronMD

Uniprot ID: Q969T3

Source protein: Sorting nexin-21

Source gene: SNX21

Class: DEG_SCF_FBW7_1

Location: 355:362

E3 ligase: FBXW7

DEGRON score: 0.7335

ASA_SCORE: 69.8625

COIL: 0.9618

CONS_SCORE: 0.4451

DSS_SCORE: 0.486

HELIX: 0.0171

FCONS_SCORE: 0.8984

RIG_SCORE: 0.655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L350P	DO222874	COCA	ICGC	LTPTPPPS	DEG_SCF_FBW7_1	0.1944
p.E370G	DO232761	PBCA	ICGC	LTPTPPPS	DEG_SCF_FBW7_1	0.1111
p.L367F	SIDM00282	Colorectal Carcinoma	GDSC	LTPTPPPS	DEG_SCF_FBW7_1	0.1944
p.L367F	CW-2	large_intestine	COSMIC	LTPTPPPS	DEG_SCF_FBW7_1	0.1944
p.R346Q	SIDM00539	Esophageal Carcinoma	GDSC	LTPTPPPS	DEG_SCF_FBW7_1	0.0833
p.P359T	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	LTPTPPPS	DEG_SCF_FBW7_1	0.7031
p.P359T	KYSE-270	oesophagus	COSMIC	LTPTPPPS	DEG_SCF_FBW7_1	0.7031
p.P350T	ACH-000873	Esophageal Cancer	CCLE	LTPTPPPS	DEG_SCF_FBW7_1	0.1944
p.P350T	KYSE-270	oesophagus	COSMIC	LTPTPPPS	DEG_SCF_FBW7_1	0.1944
p.L358F	ACH-000998	Colon/Colorectal Cancer	CCLE	LTPTPPPS	DEG_SCF_FBW7_1	0.6981
p.L358F	CW-2	large_intestine	COSMIC	LTPTPPPS	DEG_SCF_FBW7_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969T3	Sorting nexin-21	DEG_SCF_FBW7_1	355:362	LTPTPPPS	FBXW7	0.7335	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons