DegronMD - Q969U6(FBXW5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H297Y	TCGA-A5-A0G1	UCEC	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.1944
p.H297Y	DO42472	UCEC	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.1944
p.R313W	TCGA-AA-3531	COAD	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.25
p.R313W	DO9948	COAD	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.25
p.K299R	TCGA-BS-A0UF	UCEC	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation blocking ubiquitination signal	0.6944
p.K299R	DO41488	UCEC	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation blocking ubiquitination signal	0.6944
p.Q317P	TCGA-BS-A0UJ	UCEC	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.1389
p.Q317P	DO42745	UCEC	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.1389
p.E320Q	TCGA-DK-A3X1	BLCA	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.0556
p.E320Q	DO447	BLCA	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.0556
p.A298T	TCGA-EO-A3KX	UCEC	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.2222
p.A298T	DO219774	UCEC	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.2222
p.G301D	TCGA-F4-6856	COAD	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.3056
p.G301D	DO9114	COAD	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.3056
p.A296T	TCGA-L5-A4OI	ESCA	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.1667
p.R303Q	DO230343	COCA	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation altering degron motif	0.7329
p.R303Q	ACH-000999	Colon/Colorectal Cancer	CCLE	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation altering degron motif	0.7329
p.D307E	DO229037	LICA	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation altering degron motif	0.5647
p.R313Q	SIDM01943	Colorectal Carcinoma	GDSC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.25
p.S319L	SIDM00241	Breast Carcinoma	GDSC	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation rewiring degron network	0.0833
p.R308C	ACH-000359	Bone Cancer	CCLE	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation altering degron motif	0.719
p.R303W	ACH-001610	Brain Cancer	CCLE	LRHFLDRVL	DEG_APCC_DBOX_1	302:310	Mutation altering degron motif	0.8634

Kaplan plot for FBXW5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXW5

UniProt ID: Q969U6

Entrez ID: 54461

Protein name: F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXW5 in