DegronMD

Uniprot ID: Q969U6

Source protein: F-box/WD repeat-containing protein 5

Source gene: FBXW5

Class: DEG_APCC_DBOX_1

Location: 302:310

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8011

ASA_SCORE: 53.2778

COIL: 0.2591

CONS_SCORE: 0.3213

DSS_SCORE: 0.4146

HELIX: 0.0662

FCONS_SCORE: 0.9537

RIG_SCORE: 0.807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H297Y	TCGA-A5-A0G1	UCEC	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	0.1944
p.H297Y	DO42472	UCEC	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	0.1944
p.R313W	TCGA-AA-3531	COAD	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	0.25
p.R313W	DO9948	COAD	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	0.25
p.K299R	TCGA-BS-A0UF	UCEC	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	0.6944
p.K299R	DO41488	UCEC	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	0.6944
p.Q317P	TCGA-BS-A0UJ	UCEC	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	0.1389
p.Q317P	DO42745	UCEC	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	0.1389
p.E320Q	TCGA-DK-A3X1	BLCA	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	0.0556
p.E320Q	DO447	BLCA	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	0.0556
p.A298T	TCGA-EO-A3KX	UCEC	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	0.2222
p.A298T	DO219774	UCEC	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	0.2222
p.G301D	TCGA-F4-6856	COAD	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	0.3056
p.G301D	DO9114	COAD	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	0.3056
p.A296T	TCGA-L5-A4OI	ESCA	TCGA	LRHFLDRVL	DEG_APCC_DBOX_1	0.1667
p.R303Q	DO230343	COCA	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	0.7329
p.R303Q	ACH-000999	Colon/Colorectal Cancer	CCLE	LRHFLDRVL	DEG_APCC_DBOX_1	0.7329
p.D307E	DO229037	LICA	ICGC	LRHFLDRVL	DEG_APCC_DBOX_1	0.5647
p.R313Q	SIDM01943	Colorectal Carcinoma	GDSC	LRHFLDRVL	DEG_APCC_DBOX_1	0.25
p.S319L	SIDM00241	Breast Carcinoma	GDSC	LRHFLDRVL	DEG_APCC_DBOX_1	0.0833
p.R308C	ACH-000359	Bone Cancer	CCLE	LRHFLDRVL	DEG_APCC_DBOX_1	0.719
p.R303W	ACH-001610	Brain Cancer	CCLE	LRHFLDRVL	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969U6	F-box/WD repeat-containing protein 5	DEG_APCC_DBOX_1	302:310	LRHFLDRVL	APC,CDC20,FZR1	0.8011	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons