DegronMD - Q96AQ1(CCDC74A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A342V	TCGA-06-5416	GBM	TCGA	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.3056
p.A342V	ACH-002066	Sarcoma	CCLE	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.3056
p.C336F	TCGA-69-7979	LUAD	TCGA	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1389
p.R344H	TCGA-AA-A01T	COAD	TCGA	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.8244
p.A349V	TCGA-AX-A2HD	UCEC	TCGA	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.5825
p.P339L	TCGA-YD-A9TA	SKCM	TCGA	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.2222
p.R344C	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.8301
p.R344C	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.8301
p.A345V	SIDM00680	Colorectal Carcinoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.5825
p.A345V	ACH-000957	Colon/Colorectal Cancer	CCLE	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.5825
p.A345V	LS-180	large intestine	COSMIC	ERAILPALK	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.5825

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons