DegronMD

Uniprot ID: Q96AQ1

Source protein: Coiled-coil domain-containing protein 74A

Source gene: CCDC74A

Class: DEG_APCC_DBOX_1

Location: 343:351

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9195

ASA_SCORE: 66.8

COIL: 0.5244

CONS_SCORE: 0.4618

DSS_SCORE: 0.5062

HELIX: 0.3122

FCONS_SCORE: 1.4246

RIG_SCORE: 0.7717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A342V	TCGA-06-5416	GBM	TCGA	ERAILPALK	DEG_APCC_DBOX_1	0.3056
p.A342V	ACH-002066	Sarcoma	CCLE	ERAILPALK	DEG_APCC_DBOX_1	0.3056
p.C336F	TCGA-69-7979	LUAD	TCGA	ERAILPALK	DEG_APCC_DBOX_1	0.1389
p.R344H	TCGA-AA-A01T	COAD	TCGA	ERAILPALK	DEG_APCC_DBOX_1	0.8244
p.A349V	TCGA-AX-A2HD	UCEC	TCGA	ERAILPALK	DEG_APCC_DBOX_1	0.5825
p.P339L	TCGA-YD-A9TA	SKCM	TCGA	ERAILPALK	DEG_APCC_DBOX_1	0.2222
p.R344C	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.8301
p.R344C	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	ERAILPALK	DEG_APCC_DBOX_1	0.8301
p.A345V	SIDM00680	Colorectal Carcinoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.5825
p.A345V	ACH-000957	Colon/Colorectal Cancer	CCLE	ERAILPALK	DEG_APCC_DBOX_1	0.5825
p.A345V	LS-180	large_intestine	COSMIC	ERAILPALK	DEG_APCC_DBOX_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LY2	Coiled-coil domain-containing protein 74B	DEG_APCC_DBOX_1	345:353	ERAILPALK	APC,CDC20,FZR1	0.5601	More...
Q96AQ1	Coiled-coil domain-containing protein 74A	DEG_APCC_DBOX_1	343:351	ERAILPALK	APC,CDC20,FZR1	0.9195	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons