DegronMD

Uniprot ID: Q96LY2

Source protein: Coiled-coil domain-containing protein 74B

Source gene: CCDC74B

Class: DEG_APCC_DBOX_1

Location: 345:353

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5601

ASA_SCORE: 60.9778

COIL: 0.6411

CONS_SCORE: 0.4829

DSS_SCORE: 0.4298

HELIX: 0.1743

FCONS_SCORE: 1.3664

RIG_SCORE: 0.7832

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F360L	TCGA-56-8628	LUSC	TCGA	ERAILPALK	DEG_APCC_DBOX_1	0.1389
p.L339M	TCGA-AX-A2HD	UCEC	TCGA	ERAILPALK	DEG_APCC_DBOX_1	0.1667
p.E335K	DO219739	CESC	ICGC	ERAILPALK	DEG_APCC_DBOX_1	0.1667
p.A356V	DO233170	GACA	ICGC	ERAILPALK	DEG_APCC_DBOX_1	0.25
p.A339T	DO233693	GACA	ICGC	ERAILPALK	DEG_APCC_DBOX_1	0.1667
p.A339T	DO43755	UCEC	ICGC	ERAILPALK	DEG_APCC_DBOX_1	0.1667
p.A357V	DO233902	GACA	ICGC	ERAILPALK	DEG_APCC_DBOX_1	0.3333
p.A357G	DO231806	LICA	ICGC	ERAILPALK	DEG_APCC_DBOX_1	0.3333
p.M354I	DO25995	LUAD	ICGC	ERAILPALK	DEG_APCC_DBOX_1	0.3056
p.R352T	DO26846	LUSC	ICGC	ERAILPALK	DEG_APCC_DBOX_1	0.7876
p.S347I	DO228138	PBCA	ICGC	ERAILPALK	DEG_APCC_DBOX_1	0.7341
p.G355R	DO43755	UCEC	ICGC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM00608	Plasma Cell Myeloma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM00352	Ovarian Carcinoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM00544	Neuroblastoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM00238	Ovarian Carcinoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM00240	Cervical Carcinoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM00554	Ovarian Carcinoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM00026	Other Solid Cancers	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM01578	Bladder Carcinoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM01776	Plasma Cell Myeloma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM00784	Glioma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	SIDM01494	Glioblastoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	GOTO	autonomic_ganglia	COSMIC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	OMC-1	cervix	COSMIC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	KURAMOCHI	ovary	COSMIC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	RMG-I	ovary	COSMIC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.T355A	PC-14	lung	COSMIC	ERAILPALK	DEG_APCC_DBOX_1	0.2778
p.E345K	SIDM00650	Small Cell Lung Carcinoma	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.591
p.E345K	SIDM01681	Non-Cancerous	GDSC	ERAILPALK	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LY2	Coiled-coil domain-containing protein 74B	DEG_APCC_DBOX_1	345:353	ERAILPALK	APC,CDC20,FZR1	0.5601	More...
Q96AQ1	Coiled-coil domain-containing protein 74A	DEG_APCC_DBOX_1	343:351	ERAILPALK	APC,CDC20,FZR1	0.9195	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERAILPALK

Degron related mutations and impact score

Drug responses associated with CCDC74B mutations

All proteins holding degron of ERAILPALK