DegronMD - Q96AQ6(PBXIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D411Y	TCGA-62-A46O	LUAD	TCGA	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation rewiring degron network	0.2778
p.Q410P	TCGA-AP-A0LM	UCEC	TCGA	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation rewiring degron network	0.3056
p.R402Q	TCGA-BK-A6W3	UCEC	TCGA	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.7329
p.P417L	DO218419	BRCA	ICGC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation rewiring degron network	0.1111
p.H413N	DO229008	LICA	ICGC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation rewiring degron network	0.2222
p.P415S	DO219450	SKCM	ICGC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation rewiring degron network	0.1667
p.W405R	DO43025	UCEC	ICGC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.8634
p.L416F	SIDM01956	Colorectal Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation rewiring degron network	0.1389
p.L404Q	SIDM00586	Hepatocellular Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00435	Acute Myeloid Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00617	Hepatocellular Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00611	Kidney Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM01005	Acute Myeloid Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00040	Gastric Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00351	Oral Cavity Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00556	Neuroblastoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00562	Breast Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00502	B-Lymphoblastic Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00609	Kidney Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00549	B-Lymphoblastic Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00989	Bladder Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00613	Glioblastoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00603	Head and Neck Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM01439	Hepatocellular Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM01609	Endometrial Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM01617	Endometrial Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM00166	Other Solid Cancers	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM01445	Gastric Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM01691	Chronic Myelogenous Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM01559	Melanoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM01387	Small Cell Lung Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM01587	Bladder Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.L404Q	SIDM01618	B-Lymphoblastic Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6654
p.Q401R	SIDM01611	Endometrial Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6218
p.Q401R	ACH-000996	Endometrial/Uterine Cancer	CCLE	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation altering degron motif	0.6218
p.N416K	HCT-15	large intestine	COSMIC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation rewiring degron network	0.1389
p.E415D	SNU-81	large intestine	COSMIC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation rewiring degron network	0.1667
p.G418S	Sarc9371	bone	COSMIC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation rewiring degron network	0.0833
p.G399V	KCL-22	haematopoietic and lymphoid tissue	COSMIC	QRRLLGSVQ	DEG_APCC_DBOX_1	401:409	Mutation rewiring degron network	0.2778

Kaplan plot for PBXIP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PBXIP1

UniProt ID: Q96AQ6

Entrez ID: 57326

Protein name: Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PBXIP1 in