DegronMD

Uniprot ID: Q96AQ6

Source protein: Pre-B-cell leukemia transcription factor-interacting protein 1

Source gene: PBXIP1

Class: DEG_APCC_DBOX_1

Location: 401:409

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7473

ASA_SCORE: 101.1556

COIL: 0.4247

CONS_SCORE: 0.8328

DSS_SCORE: 0.4213

HELIX: 0.5701

FCONS_SCORE: 1.0391

RIG_SCORE: 0.7325

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D411Y	TCGA-62-A46O	LUAD	TCGA	QRRLLGSVQ	DEG_APCC_DBOX_1	0.2778
p.Q410P	TCGA-AP-A0LM	UCEC	TCGA	QRRLLGSVQ	DEG_APCC_DBOX_1	0.3056
p.R402Q	TCGA-BK-A6W3	UCEC	TCGA	QRRLLGSVQ	DEG_APCC_DBOX_1	0.7329
p.P417L	DO218419	BRCA	ICGC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.1111
p.H413N	DO229008	LICA	ICGC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.2222
p.P415S	DO219450	SKCM	ICGC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.1667
p.W405R	DO43025	UCEC	ICGC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.8634
p.L416F	SIDM01956	Colorectal Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.1389
p.L404Q	SIDM00586	Hepatocellular Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00435	Acute Myeloid Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00617	Hepatocellular Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00611	Kidney Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM01005	Acute Myeloid Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00040	Gastric Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00351	Oral Cavity Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00556	Neuroblastoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00562	Breast Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00502	B-Lymphoblastic Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00609	Kidney Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00549	B-Lymphoblastic Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00989	Bladder Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00613	Glioblastoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00603	Head and Neck Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM01439	Hepatocellular Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM01609	Endometrial Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM01617	Endometrial Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM00166	Other Solid Cancers	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM01445	Gastric Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM01691	Chronic Myelogenous Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM01559	Melanoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM01387	Small Cell Lung Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM01587	Bladder Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.L404Q	SIDM01618	B-Lymphoblastic Leukemia	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6654
p.Q401R	SIDM01611	Endometrial Carcinoma	GDSC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6218
p.Q401R	ACH-000996	Endometrial/Uterine Cancer	CCLE	QRRLLGSVQ	DEG_APCC_DBOX_1	0.6218
p.N416K	HCT-15	large_intestine	COSMIC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.1389
p.E415D	SNU-81	large_intestine	COSMIC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.1667
p.G418S	Sarc9371	bone	COSMIC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.0833
p.G399V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	QRRLLGSVQ	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRRLLGSVQ

Degron related mutations and impact score

Drug responses associated with PBXIP1 mutations

All proteins holding degron of QRRLLGSVQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AQ6	Pre-B-cell leukemia transcription factor-interacting protein 1	DEG_APCC_DBOX_1	401:409	QRRLLGSVQ	APC,CDC20,FZR1	0.7473	More...