DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
LENG9
UniProt ID:
Q96B70
Entrez ID:
94059
Protein name:
Leukocyte receptor cluster member 9
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
...
View more >>
GO - Biological processes (BP):
...
View more >>
GO - Molecular function (MF):
metal ion binding [GO:0046872]...
metal ion binding [GO:0046872]
View more >>
GO - Cellular component (CC):
...
View more >>
Choose a PDB ID:
Open in full screen with detailed sequence annotations
LENG9
Control panel
Show dataset:
All datasets
TCGA
ICGC
COSMIC
CCLE
GDSC
Show Degron:
All sites
Degron
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Add PTM sites
Phosphorylation
Legend: PTM sites
Data table is loading....
AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.E262A
DO222869
COCA
ICGC
PRGRLAGVT
DEG_APCC_DBOX_1
252:260
Mutation rewiring degron network
0.2778
p.E262A
DO229242
THCA
ICGC
PRGRLAGVT
DEG_APCC_DBOX_1
252:260
Mutation rewiring degron network
0.2778
p.R255C
ACH-000659
Lung Cancer
CCLE
PRGRLAGVT
DEG_APCC_DBOX_1
252:260
Mutation altering degron motif
0.719
p.R255C
ACH-001386
Lung Cancer
CCLE
PRGRLAGVT
DEG_APCC_DBOX_1
252:260
Mutation altering degron motif
0.719
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for LENG9 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc