DegronMD

Uniprot ID: Q96B70

Source protein: Leukocyte receptor cluster member 9

Source gene: LENG9

Class: DEG_APCC_DBOX_1

Location: 252:260

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7063

ASA_SCORE: 67.9889

COIL: 0.5921

CONS_SCORE: 0.4287

DSS_SCORE: 0.4759

HELIX: 0.2259

FCONS_SCORE: 1.0392

RIG_SCORE: 0.7304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E262A	DO222869	COCA	ICGC	PRGRLAGVT	DEG_APCC_DBOX_1	0.2778
p.E262A	DO229242	THCA	ICGC	PRGRLAGVT	DEG_APCC_DBOX_1	0.2778
p.R255C	ACH-000659	Lung Cancer	CCLE	PRGRLAGVT	DEG_APCC_DBOX_1	0.719
p.R255C	ACH-001386	Lung Cancer	CCLE	PRGRLAGVT	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96B70	Leukocyte receptor cluster member 9	DEG_APCC_DBOX_1	252:260	PRGRLAGVT	APC,CDC20,FZR1	0.7063	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons