DegronMD - Q96BR6(ZNF669)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E37Q	TCGA-LP-A5U2	CESC	TCGA	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.E37Q	DO51610	CESC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.R30T	DO44299	CESC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.6765
p.G44D	DO227987	COCA	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.0833
p.G44D	SIDM01156	Small Cell Lung Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.0833
p.G44D	ACH-000890	Lung Cancer	CCLE	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.0833
p.G44D	SW1271	lung	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.0833
p.K18N	DO234199	ESAD	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation substituting flanking lysine	0.1944
p.E43G	DO17801	KIRC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1111
p.R38G	DO228941	LICA	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.25
p.R38G	DO219146	LUSC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.25
p.R38G	SNU-475	liver	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.25
p.C37F	DO228960	LICA	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.Q25K	DO229026	LICA	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.R43W	DO229035	LICA	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1111
p.R30G	DO231124	LUSC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.6457
p.W18L	DO37523	SKCM	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation substituting flanking lysine	0.1944
p.W18L	DO37715	SKCM	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation substituting flanking lysine	0.1944
p.A44V	DO37891	SKCM	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.0833
p.S23F	DO52402	UCEC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2222
p.L28F	DO42793	UCEC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.6981
p.A20V	SIDM00216	Colorectal Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1389
p.A20V	SIDM01660	Kidney Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1389
p.A20V	ACH-000709	Kidney Cancer	CCLE	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1389
p.A20V	ACH-000989	Colon/Colorectal Cancer	CCLE	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1389
p.A20V	SNU-175	large intestine	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1389
p.R30L	SIDM00553	Acute Myeloid Leukemia	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.R30L	SIDM00301	Pancreatic Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.R30L	SIDM01061	Oral Cavity Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.R30L	SIDM00165	Other Solid Cancers	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.R30L	SIDM01463	Endometrial Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.R30L	SIDM00173	Head and Neck Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.R30L	SIDM01442	Glioma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.R30L	HN	upper aerodigestive tract	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.R30L	HCC-56	large intestine	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.R30L	KY821	haematopoietic and lymphoid tissue	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.R30L	KP-4	pancreas	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7316
p.S42G	SIDM01045	Endometrial Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1389
p.S42G	ACH-000978	Endometrial/Uterine Cancer	CCLE	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1389
p.S42G	EN	endometrium	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1389
p.R41P	SIDM00901	Endometrial Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1667
p.R41P	ACH-000940	Endometrial/Uterine Cancer	CCLE	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1667
p.R41P	AN3-CA	endometrium	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF669

UniProt ID: Q96BR6

Entrez ID: 79862

Protein name: Zinc finger protein 669

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF669 in