DegronMD

Uniprot ID: Q96BR6

Source protein: Zinc finger protein 669

Source gene: ZNF669

Class: DEG_APCC_DBOX_1

Location: 27:35

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8979

ASA_SCORE: 101.1

COIL: 0.6052

CONS_SCORE: 0.3307

DSS_SCORE: 0.4891

HELIX: 0.3802

FCONS_SCORE: 1.7927

RIG_SCORE: 0.7309

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E37Q	TCGA-LP-A5U2	CESC	TCGA	PRHRLRNLR	DEG_APCC_DBOX_1	0.2778
p.E37Q	DO51610	CESC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.2778
p.R30T	DO44299	CESC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.6765
p.G44D	DO227987	COCA	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.0833
p.G44D	SIDM01156	Small Cell Lung Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.0833
p.G44D	ACH-000890	Lung Cancer	CCLE	PRHRLRNLR	DEG_APCC_DBOX_1	0.0833
p.G44D	SW1271	lung	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	0.0833
p.K18N	DO234199	ESAD	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1944
p.E43G	DO17801	KIRC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1111
p.R38G	DO228941	LICA	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.25
p.R38G	DO219146	LUSC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.25
p.R38G	SNU-475	liver	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	0.25
p.C37F	DO228960	LICA	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.2778
p.Q25K	DO229026	LICA	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.2778
p.R43W	DO229035	LICA	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1111
p.R30G	DO231124	LUSC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.6457
p.W18L	DO37523	SKCM	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1944
p.W18L	DO37715	SKCM	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1944
p.A44V	DO37891	SKCM	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.0833
p.S23F	DO52402	UCEC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.2222
p.L28F	DO42793	UCEC	ICGC	PRHRLRNLR	DEG_APCC_DBOX_1	0.6981
p.A20V	SIDM00216	Colorectal Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1389
p.A20V	SIDM01660	Kidney Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1389
p.A20V	ACH-000709	Kidney Cancer	CCLE	PRHRLRNLR	DEG_APCC_DBOX_1	0.1389
p.A20V	ACH-000989	Colon/Colorectal Cancer	CCLE	PRHRLRNLR	DEG_APCC_DBOX_1	0.1389
p.A20V	SNU-175	large_intestine	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1389
p.R30L	SIDM00553	Acute Myeloid Leukemia	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.R30L	SIDM00301	Pancreatic Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.R30L	SIDM01061	Oral Cavity Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.R30L	SIDM00165	Other Solid Cancers	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.R30L	SIDM01463	Endometrial Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.R30L	SIDM00173	Head and Neck Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.R30L	SIDM01442	Glioma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.R30L	HN	upper_aerodigestive_tract	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.R30L	HCC-56	large_intestine	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.R30L	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.R30L	KP-4	pancreas	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	0.7316
p.S42G	SIDM01045	Endometrial Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1389
p.S42G	ACH-000978	Endometrial/Uterine Cancer	CCLE	PRHRLRNLR	DEG_APCC_DBOX_1	0.1389
p.S42G	EN	endometrium	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1389
p.R41P	SIDM00901	Endometrial Carcinoma	GDSC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1667
p.R41P	ACH-000940	Endometrial/Uterine Cancer	CCLE	PRHRLRNLR	DEG_APCC_DBOX_1	0.1667
p.R41P	AN3-CA	endometrium	COSMIC	PRHRLRNLR	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRHRLRNLR

Degron related mutations and impact score

Drug responses associated with ZNF669 mutations

All proteins holding degron of PRHRLRNLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BR6	Zinc finger protein 669	DEG_APCC_DBOX_1	27:35	PRHRLRNLR	APC,CDC20,FZR1	0.8979	More...