DegronMD - Q96C03(MIEF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L128I	TCGA-HF-A5NB	STAD	TCGA	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation rewiring degron network	0.0556
p.L128I	DO50127	STAD	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation rewiring degron network	0.0556
p.G104D	DO11854	GBM	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation rewiring degron network	0.1389
p.G104D	DO11854	GBM	ICGC	APSSS	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.V114F	DO228985	LICA	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation altering degron motif	0.7068
p.C115F	DO229015	LICA	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation altering degron motif	0.7108
p.S111C	DO26469	LUSC	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation altering degron motif	0.7541
p.G108S	DO229213	THCA	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation rewiring degron network	0.25
p.G108S	DO229213	THCA	ICGC	APSSS	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.1389
p.H116N	DO41999	UCEC	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation altering degron motif	0.7423
p.S111L	SIDM00535	Chondrosarcoma	GDSC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation altering degron motif	0.7667
p.S111L	SIDM00457	Plasma Cell Myeloma	GDSC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation altering degron motif	0.7667
p.S111L	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation altering degron motif	0.7667
p.S111L	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation altering degron motif	0.7667
p.R94W	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.R94W	OE21	oesophagus	COSMIC	APSSS	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.S119F	ACH-000135	Non-Cancerous	CCLE	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation rewiring degron network	0.3056
p.S119F	Hs940-T	skin	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation rewiring degron network	0.3056
p.P112H	KM12	large intestine	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation altering degron motif	0.7694
p.P110S	MCC13	skin	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation rewiring degron network	0.3056
p.P110S	MCC13	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0833
p.L109P	KY821	haematopoietic and lymphoid tissue	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation rewiring degron network	0.2778
p.L109P	KY821	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.1111
p.V107I	LCLC-103H	lung	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation rewiring degron network	0.2222
p.V107I	LCLC-103H	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.1667
p.R110Q	LOU-NH91	lung	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	111:118	Mutation rewiring degron network	0.3056
p.R110Q	LOU-NH91	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0833

Kaplan plot for MIEF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MIEF2

UniProt ID: Q96C03

Entrez ID: 125170

Protein name: Mitochondrial dynamics protein MID49 (Mitochondrial dynamics protein of 49 kDa) (Mitochondrial elongation factor 2) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MIEF2 in