DegronMD

Uniprot ID: Q96C03

Source protein: Mitochondrial dynamics protein MID49

Source gene: MIEF2

Class: DEG_SCF_FBW7_1

Location: 111:118

E3 ligase: FBXW7

DEGRON score: 0.7862

ASA_SCORE: 81.6

COIL: 0.8144

CONS_SCORE: 0.233

DSS_SCORE: 0.6583

HELIX: 0.1213

FCONS_SCORE: 0.6321

RIG_SCORE: 0.664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L128I	TCGA-HF-A5NB	STAD	TCGA	PEVTPQLS	DEG_SCF_FBW7_1	0.0556
p.L128I	DO50127	STAD	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	0.0556
p.G104D	DO11854	GBM	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	0.1389
p.V114F	DO228985	LICA	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	0.7068
p.C115F	DO229015	LICA	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	0.7108
p.S111C	DO26469	LUSC	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	0.7541
p.G108S	DO229213	THCA	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	0.25
p.H116N	DO41999	UCEC	ICGC	PEVTPQLS	DEG_SCF_FBW7_1	0.7423
p.S111L	SIDM00535	Chondrosarcoma	GDSC	PEVTPQLS	DEG_SCF_FBW7_1	0.7667
p.S111L	SIDM00457	Plasma Cell Myeloma	GDSC	PEVTPQLS	DEG_SCF_FBW7_1	0.7667
p.S111L	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PEVTPQLS	DEG_SCF_FBW7_1	0.7667
p.S111L	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PEVTPQLS	DEG_SCF_FBW7_1	0.7667
p.S119F	ACH-000135	Non-Cancerous	CCLE	PEVTPQLS	DEG_SCF_FBW7_1	0.3056
p.S119F	Hs940-T	skin	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	0.3056
p.P112H	KM12	large_intestine	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	0.7694
p.P110S	MCC13	skin	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	0.3056
p.L109P	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	0.2778
p.V107I	LCLC-103H	lung	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	0.2222
p.R110Q	LOU-NH91	lung	COSMIC	PEVTPQLS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96C03	Mitochondrial dynamics protein MID49	DEG_SCF_FBW7_1	111:118	PEVTPQLS	FBXW7	0.7862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons