DegronMD - Q96C19(EFHD2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q93H	TCGA-86-7955	LUAD	TCGA	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.Q93H	DO23612	LUAD	ICGC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.V79I	TCGA-AZ-6598	COAD	TCGA	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.V79I	DO10276	COAD	ICGC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.3056
p.F89L	TCGA-BS-A0UF	UCEC	TCGA	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2222
p.F89L	DO41488	UCEC	ICGC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.2222
p.S90Y	TCGA-D3-A2JC	SKCM	TCGA	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.S90Y	DO47578	SKCM	ICGC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1944
p.E88G	TCGA-XK-AAIW	PRAD	TCGA	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.E88G	DO51407	PRAD	ICGC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.E88D	DO228974	LICA	ICGC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.25
p.K87M	DO229218	THCA	ICGC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation blocking ubiquitination signal	0.7222
p.P72S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.P72S	ACH-000656	Lymphoma	CCLE	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.P72S	SU-DHL-8	NS	COSMIC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation rewiring degron network	0.1111
p.K92M	SIDM01086	B-Lymphoblastic Leukemia	GDSC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation substituting flanking lysine	0.25
p.K92M	ACH-000874	Leukemia	CCLE	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation substituting flanking lysine	0.25
p.K92M	RS4-11	haematopoietic and lymphoid tissue	COSMIC	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation substituting flanking lysine	0.25
p.Y83C	ACH-000994	Endometrial/Uterine Cancer	CCLE	FNPYTE	LIG_APCC_ABBA_1	80:85	Mutation altering degron motif	0.8198

Kaplan plot for EFHD2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFHD2

UniProt ID: Q96C19

Entrez ID: 79180

Protein name: EF-hand domain-containing protein D2 (Swiprosin-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for EFHD2 in