DegronMD

Uniprot ID: Q96C19

Source protein: EF-hand domain-containing protein D2

Source gene: EFHD2

Class: LIG_APCC_ABBA_1

Location: 80:85

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.995

ASA_SCORE: 52.8167

COIL: 0.5792

CONS_SCORE: 0.7264

DSS_SCORE: 0.4764

HELIX: 0.3447

FCONS_SCORE: 1.031

RIG_SCORE: 0.7581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q93H	TCGA-86-7955	LUAD	TCGA	FNPYTE	LIG_APCC_ABBA_1	0.1111
p.Q93H	DO23612	LUAD	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.1111
p.V79I	TCGA-AZ-6598	COAD	TCGA	FNPYTE	LIG_APCC_ABBA_1	0.3056
p.V79I	DO10276	COAD	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.3056
p.F89L	TCGA-BS-A0UF	UCEC	TCGA	FNPYTE	LIG_APCC_ABBA_1	0.2222
p.F89L	DO41488	UCEC	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.2222
p.S90Y	TCGA-D3-A2JC	SKCM	TCGA	FNPYTE	LIG_APCC_ABBA_1	0.1944
p.S90Y	DO47578	SKCM	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.1944
p.E88G	TCGA-XK-AAIW	PRAD	TCGA	FNPYTE	LIG_APCC_ABBA_1	0.25
p.E88G	DO51407	PRAD	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.25
p.E88D	DO228974	LICA	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.25
p.K87M	DO229218	THCA	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.7222
p.P72S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	FNPYTE	LIG_APCC_ABBA_1	0.1111
p.P72S	ACH-000656	Lymphoma	CCLE	FNPYTE	LIG_APCC_ABBA_1	0.1111
p.P72S	SU-DHL-8	NS	COSMIC	FNPYTE	LIG_APCC_ABBA_1	0.1111
p.K92M	SIDM01086	B-Lymphoblastic Leukemia	GDSC	FNPYTE	LIG_APCC_ABBA_1	0.25
p.K92M	ACH-000874	Leukemia	CCLE	FNPYTE	LIG_APCC_ABBA_1	0.25
p.K92M	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	FNPYTE	LIG_APCC_ABBA_1	0.25
p.Y83C	ACH-000994	Endometrial/Uterine Cancer	CCLE	FNPYTE	LIG_APCC_ABBA_1	0.8198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUP0	EF-hand domain-containing protein D1	LIG_APCC_ABBA_1	78:83	FNPYTE	APC,CDC20,FZR1	0.9727	More...
Q96C19	EF-hand domain-containing protein D2	LIG_APCC_ABBA_1	80:85	FNPYTE	APC,CDC20,FZR1	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons