DegronMD - Q9BUP0(EFHD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R73W	TCGA-XK-AAIW	PRAD	TCGA	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.1944
p.R73W	TCGA-XK-AAIW	PRAD	TCGA	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.1667
p.R73W	DO51407	PRAD	ICGC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.1944
p.R73W	DO51407	PRAD	ICGC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.1667
p.P72S	DO233123	GACA	ICGC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.1667
p.P72S	DO233123	GACA	ICGC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.1389
p.R89H	DO232829	NACA	ICGC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.1667
p.R89H	DO232829	NACA	ICGC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.2222
p.R89H	DO233298	NACA	ICGC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.1667
p.R89H	DO233298	NACA	ICGC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.2222
p.D94Y	DO232224	PBCA	ICGC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.0833
p.S89L	DO51112	PRAD	ICGC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.1667
p.S89L	DO51112	PRAD	ICGC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.2222
p.E94K	DO37448	SKCM	ICGC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.0833
p.R90H	SIDM02035	Colorectal Carcinoma	GDSC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.1389
p.R90H	SIDM02035	Colorectal Carcinoma	GDSC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.1944
p.S88N	SIDM01617	Endometrial Carcinoma	GDSC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.1944
p.S88N	SIDM01617	Endometrial Carcinoma	GDSC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.25
p.S88N	ACH-000994	Endometrial/Uterine Cancer	CCLE	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.1944
p.S88N	ACH-000994	Endometrial/Uterine Cancer	CCLE	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.25
p.K92N	HCC2998	large intestine	COSMIC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.0833
p.K92N	HCC2998	large intestine	COSMIC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.1389
p.R76W	NCI-H1650	lung	COSMIC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.2778
p.R76W	NCI-H1650	lung	COSMIC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.25
p.K77N	HCC2998	large intestine	COSMIC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation rewiring degron network	0.3056
p.K77N	HCC2998	large intestine	COSMIC	NPYTEFP	CBL_PTK	79:85	Mutation rewiring degron network	0.2778
p.K93N	HCC2998	large intestine	COSMIC	FNPYTE	LIG_APCC_ABBA_1	78:83	Mutation substituting flanking lysine	0.1667
p.K93N	HCC2998	large intestine	COSMIC	NPYTEFP	CBL_PTK	79:85	Mutation substituting flanking lysine	0.2222

Kaplan plot for EFHD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFHD1

UniProt ID: Q9BUP0

Entrez ID: 80303

Protein name: EF-hand domain-containing protein D1 (EF-hand domain-containing protein 1) (Swiprosin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFHD1 in