DegronMD

Uniprot ID: Q9BUP0

Source protein: EF-hand domain-containing protein D1

Source gene: EFHD1

Class: LIG_APCC_ABBA_1

Location: 78:83

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9727

ASA_SCORE: 75.95

COIL: 0.8252

CONS_SCORE: 0.6623

DSS_SCORE: 0.2177

HELIX: 0.0903

FCONS_SCORE: 1.2092

RIG_SCORE: 0.7921

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R73W	TCGA-XK-AAIW	PRAD	TCGA	FNPYTE	LIG_APCC_ABBA_1	0.1944
p.R73W	DO51407	PRAD	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.1944
p.P72S	DO233123	GACA	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.1667
p.R89H	DO232829	NACA	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.1667
p.R89H	DO233298	NACA	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.1667
p.S89L	DO51112	PRAD	ICGC	FNPYTE	LIG_APCC_ABBA_1	0.1667
p.R90H	SIDM02035	Colorectal Carcinoma	GDSC	FNPYTE	LIG_APCC_ABBA_1	0.1389
p.S88N	SIDM01617	Endometrial Carcinoma	GDSC	FNPYTE	LIG_APCC_ABBA_1	0.1944
p.S88N	ACH-000994	Endometrial/Uterine Cancer	CCLE	FNPYTE	LIG_APCC_ABBA_1	0.1944
p.K92N	HCC2998	large_intestine	COSMIC	FNPYTE	LIG_APCC_ABBA_1	0.0833
p.R76W	NCI-H1650	lung	COSMIC	FNPYTE	LIG_APCC_ABBA_1	0.2778
p.K77N	HCC2998	large_intestine	COSMIC	FNPYTE	LIG_APCC_ABBA_1	0.3056
p.K93N	HCC2998	large_intestine	COSMIC	FNPYTE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUP0	EF-hand domain-containing protein D1	LIG_APCC_ABBA_1	78:83	FNPYTE	APC,CDC20,FZR1	0.9727	More...
Q96C19	EF-hand domain-containing protein D2	LIG_APCC_ABBA_1	80:85	FNPYTE	APC,CDC20,FZR1	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons