DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NPYTEFP
Uniprot ID:
Q9BUP0
Source protein:
EF-hand domain-containing protein D1
Source gene:
EFHD1
Class:
CBL_PTK
Location:
79:85
E3 ligase:
CBL
DEGRON score:
0.9509
ASA_SCORE:
68.8714
COIL:
0.8383
CONS_SCORE:
0.6812
DSS_SCORE:
0.1819
HELIX:
0.0974
FCONS_SCORE:
1.2425
RIG_SCORE:
0.8079
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R73W
TCGA-XK-AAIW
PRAD
TCGA
NPYTEFP
CBL_PTK
0.1667
p.R73W
DO51407
PRAD
ICGC
NPYTEFP
CBL_PTK
0.1667
p.P72S
DO233123
GACA
ICGC
NPYTEFP
CBL_PTK
0.1389
p.R89H
DO232829
NACA
ICGC
NPYTEFP
CBL_PTK
0.2222
p.R89H
DO233298
NACA
ICGC
NPYTEFP
CBL_PTK
0.2222
p.D94Y
DO232224
PBCA
ICGC
NPYTEFP
CBL_PTK
0.0833
p.S89L
DO51112
PRAD
ICGC
NPYTEFP
CBL_PTK
0.2222
p.E94K
DO37448
SKCM
ICGC
NPYTEFP
CBL_PTK
0.0833
p.R90H
SIDM02035
Colorectal Carcinoma
GDSC
NPYTEFP
CBL_PTK
0.1944
p.S88N
SIDM01617
Endometrial Carcinoma
GDSC
NPYTEFP
CBL_PTK
0.25
p.S88N
ACH-000994
Endometrial/Uterine Cancer
CCLE
NPYTEFP
CBL_PTK
0.25
p.K92N
HCC2998
large_intestine
COSMIC
NPYTEFP
CBL_PTK
0.1389
p.R76W
NCI-H1650
lung
COSMIC
NPYTEFP
CBL_PTK
0.25
p.K77N
HCC2998
large_intestine
COSMIC
NPYTEFP
CBL_PTK
0.2778
p.K93N
HCC2998
large_intestine
COSMIC
NPYTEFP
CBL_PTK
0.2222
Drug responses associated with EFHD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPYTEFP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BUP0
EF-hand domain-containing protein D1
CBL_PTK
79:85
NPYTEFP
CBL
0.9509
More...
