DegronMD - Q96CJ1(EAF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R99W	TCGA-A5-A2K5	UCEC	TCGA	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.2778
p.R99W	TCGA-F5-6814	READ	TCGA	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.2778
p.R99W	DO36556	READ	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.2778
p.R99W	DO41379	UCEC	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.2778
p.Y83D	TCGA-CA-6717	COAD	TCGA	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.0833
p.Y83D	DO8264	COAD	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.0833
p.R99Q	TCGA-CM-6674	COAD	TCGA	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.2778
p.R99Q	DO10092	COAD	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.2778
p.C98G	TCGA-E6-A1LX	UCEC	TCGA	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.3056
p.C98G	DO41020	UCEC	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.3056
p.I91S	TCGA-EO-A22X	UCEC	TCGA	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.3056
p.I91S	DO43907	UCEC	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.3056
p.C87S	DO1014	BRCA	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.1944
p.C98F	DO228971	LICA	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.3056
p.C98F	DO229031	LICA	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.3056
p.R99L	DO229038	LICA	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.2778
p.I88V	DO229208	THCA	ICGC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.2222
p.L89F	SIDM01503	Small Cell Lung Carcinoma	GDSC	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.25
p.L89F	ACH-000844	Lung Cancer	CCLE	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.25
p.P82L	ACH-001566	Skin Cancer	CCLE	NHDTGE	DEG_Kelch_Keap1_1	92:97	Mutation rewiring degron network	0.0556

Kaplan plot for EAF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EAF2

UniProt ID: Q96CJ1

Entrez ID: 55840

Protein name: ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EAF2 in