DegronMD

Uniprot ID: Q96CJ1

Source protein: ELL-associated factor 2

Source gene: EAF2

Class: DEG_Kelch_Keap1_1

Location: 92:97

E3 ligase: KEAP1

DEGRON score: 0.8143

ASA_SCORE: 64.3167

COIL: 0.7003

CONS_SCORE: 0.6131

DSS_SCORE: 0.1411

HELIX: 0.0115

FCONS_SCORE: 0.9081

RIG_SCORE: 0.8593

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R99W	TCGA-A5-A2K5	UCEC	TCGA	NHDTGE	DEG_Kelch_Keap1_1	0.2778
p.R99W	TCGA-F5-6814	READ	TCGA	NHDTGE	DEG_Kelch_Keap1_1	0.2778
p.R99W	DO36556	READ	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.2778
p.R99W	DO41379	UCEC	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.2778
p.Y83D	TCGA-CA-6717	COAD	TCGA	NHDTGE	DEG_Kelch_Keap1_1	0.0833
p.Y83D	DO8264	COAD	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.0833
p.R99Q	TCGA-CM-6674	COAD	TCGA	NHDTGE	DEG_Kelch_Keap1_1	0.2778
p.R99Q	DO10092	COAD	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.2778
p.C98G	TCGA-E6-A1LX	UCEC	TCGA	NHDTGE	DEG_Kelch_Keap1_1	0.3056
p.C98G	DO41020	UCEC	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.3056
p.I91S	TCGA-EO-A22X	UCEC	TCGA	NHDTGE	DEG_Kelch_Keap1_1	0.3056
p.I91S	DO43907	UCEC	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.3056
p.C87S	DO1014	BRCA	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.1944
p.C98F	DO228971	LICA	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.3056
p.C98F	DO229031	LICA	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.3056
p.R99L	DO229038	LICA	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.2778
p.I88V	DO229208	THCA	ICGC	NHDTGE	DEG_Kelch_Keap1_1	0.2222
p.L89F	SIDM01503	Small Cell Lung Carcinoma	GDSC	NHDTGE	DEG_Kelch_Keap1_1	0.25
p.L89F	ACH-000844	Lung Cancer	CCLE	NHDTGE	DEG_Kelch_Keap1_1	0.25
p.P82L	ACH-001566	Skin Cancer	CCLE	NHDTGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CJ1	ELL-associated factor 2	DEG_Kelch_Keap1_1	92:97	NHDTGE	KEAP1	0.8143	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons