DegronMD - Q96CS3(FAF2)

FAF2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E399D	TCGA-61-2087	OV	TCGA	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation rewiring degron network	0.0833
p.E399D	DO32039	OV	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation rewiring degron network	0.0833
p.P408S	TCGA-90-A4ED	LUSC	TCGA	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation altering degron motif	0.5641
p.P408S	TCGA-AP-A059	UCEC	TCGA	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation altering degron motif	0.5641
p.P408S	DO45482	LUSC	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation altering degron motif	0.5641
p.P408S	DO41361	UCEC	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation altering degron motif	0.5641
p.P408L	TCGA-D6-6516	HNSC	TCGA	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation altering degron motif	0.6471
p.P408L	DO15623	HNSC	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation altering degron motif	0.6471
p.P421S	TCGA-FI-A2D5	UCEC	TCGA	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation rewiring degron network	0.1944
p.P421S	DO41331	UCEC	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation rewiring degron network	0.1944
p.P413H	DO230346	COCA	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation altering degron motif	0.6583
p.V411L	DO228978	LICA	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation altering degron motif	0.5654
p.P413S	DO228138	PBCA	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	408:416	Mutation altering degron motif	0.5641

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*NOTE: the Kaplan plots were collected from OncoLnc