DegronMD

Uniprot ID: Q96CS3

Source protein: FAS-associated factor 2

Source gene: FAF2

Class: DEG_APCC_DBOX_1

Location: 408:416

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9187

ASA_SCORE: 55.0556

COIL: 0.6614

CONS_SCORE: 0.5342

DSS_SCORE: 0.3332

HELIX: 0.0133

FCONS_SCORE: 1.162

RIG_SCORE: 0.7809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E399D	TCGA-61-2087	OV	TCGA	PRRVLPCIP	DEG_APCC_DBOX_1	0.0833
p.E399D	DO32039	OV	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	0.0833
p.P408S	TCGA-90-A4ED	LUSC	TCGA	PRRVLPCIP	DEG_APCC_DBOX_1	0.5641
p.P408S	TCGA-AP-A059	UCEC	TCGA	PRRVLPCIP	DEG_APCC_DBOX_1	0.5641
p.P408S	DO45482	LUSC	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	0.5641
p.P408S	DO41361	UCEC	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	0.5641
p.P408L	TCGA-D6-6516	HNSC	TCGA	PRRVLPCIP	DEG_APCC_DBOX_1	0.6471
p.P408L	DO15623	HNSC	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	0.6471
p.P421S	TCGA-FI-A2D5	UCEC	TCGA	PRRVLPCIP	DEG_APCC_DBOX_1	0.1944
p.P421S	DO41331	UCEC	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	0.1944
p.P413H	DO230346	COCA	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	0.6583
p.V411L	DO228978	LICA	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	0.5654
p.P413S	DO228138	PBCA	ICGC	PRRVLPCIP	DEG_APCC_DBOX_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CS3	FAS-associated factor 2	DEG_APCC_DBOX_1	408:416	PRRVLPCIP	APC,CDC20,FZR1	0.9187	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons