DegronMD - Q96CT2(KLHL29)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G42S	TCGA-A6-6781	COAD	TCGA	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1389
p.G42S	DO8447	COAD	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1389
p.A39S	DO224876	BRCA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.0556
p.A39S	DO52552	BRCA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.0556
p.G40S	DO233194	GACA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.0833
p.G40S	DO38404	STAD	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.0833
p.G40V	DO229015	LICA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.0833
p.A44S	DO229045	LICA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1944
p.V58M	DO229268	THCA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.3056
p.P64S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.1389
p.P60L	ACH-000607	Rhabdoid	CCLE	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.25
p.P66L	ACH-000936	Ovarian Cancer	CCLE	VRPGLLPLP	DEG_APCC_DBOX_1	49:57	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons