DegronMD

Uniprot ID: Q96CT2

Source protein: Kelch-like protein 29

Source gene: KLHL29

Class: DEG_APCC_DBOX_1

Location: 49:57

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9418

ASA_SCORE: 62.8556

COIL: 0.6899

CONS_SCORE: 0.4

DSS_SCORE: 0.4302

HELIX: 0.0327

FCONS_SCORE: 0.8358

RIG_SCORE: 0.7288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G42S	TCGA-A6-6781	COAD	TCGA	VRPGLLPLP	DEG_APCC_DBOX_1	0.1389
p.G42S	DO8447	COAD	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	0.1389
p.A39S	DO224876	BRCA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	0.0556
p.A39S	DO52552	BRCA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	0.0556
p.G40S	DO233194	GACA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	0.0833
p.G40S	DO38404	STAD	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	0.0833
p.G40V	DO229015	LICA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	0.0833
p.A44S	DO229045	LICA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	0.1944
p.V58M	DO229268	THCA	ICGC	VRPGLLPLP	DEG_APCC_DBOX_1	0.3056
p.P64S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VRPGLLPLP	DEG_APCC_DBOX_1	0.1389
p.P60L	ACH-000607	Rhabdoid	CCLE	VRPGLLPLP	DEG_APCC_DBOX_1	0.25
p.P66L	ACH-000936	Ovarian Cancer	CCLE	VRPGLLPLP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CT2	Kelch-like protein 29	DEG_APCC_DBOX_1	49:57	VRPGLLPLP	APC,CDC20,FZR1	0.9418	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons