DegronMD - Q96CV9(OPTN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R520C	TCGA-A5-A0G2	UCEC	TCGA	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.2778
p.R520C	DO41235	UCEC	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.2778
p.G509R	TCGA-BR-8060	STAD	TCGA	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.3056
p.G509R	DO38205	STAD	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.3056
p.K501E	TCGA-IG-A5B8	ESCA	TCGA	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation blocking ubiquitination signal	0.5278
p.A523V	DO222737	COCA	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.1944
p.R511S	DO228929	LICA	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.7427
p.G522V	DO228971	LICA	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.2222
p.G522V	DO229041	LICA	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.2222
p.E516Q	SIDM00934	Pancreatic Carcinoma	GDSC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.5633
p.E516Q	ACH-000354	Pancreatic Cancer	CCLE	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.5633
p.E516Q	CAPAN-1	pancreas	COSMIC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.5633
p.R524K	SIDM00537	Colorectal Carcinoma	GDSC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.1667
p.R524K	ACH-000982	Colon/Colorectal Cancer	CCLE	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.1667
p.R524K	ACH-001345	Colon/Colorectal Cancer	CCLE	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.1667
p.R524K	GP5d	large intestine	COSMIC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation rewiring degron network	0.1667
p.T525A	SIDM01608	Endometrial Carcinoma	GDSC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation blocking phosphorylation signal	0.5833
p.T525A	ACH-000990	Endometrial/Uterine Cancer	CCLE	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation blocking phosphorylation signal	0.5833
p.R518K	GP5d	large intestine	COSMIC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.7237
p.E510Q	CAPAN-1	pancreas	COSMIC	GRQSLMEMQ	DEG_APCC_DBOX_1	510:518	Mutation altering degron motif	0.6744

Kaplan plot for OPTN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OPTN

UniProt ID: Q96CV9

Entrez ID: 10133

Protein name: Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OPTN in