DegronMD

Uniprot ID: Q96CV9

Source protein: Optineurin

Source gene: OPTN

Class: DEG_APCC_DBOX_1

Location: 510:518

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.687

ASA_SCORE: 104.8667

COIL: 0.1387

CONS_SCORE: 0.6227

DSS_SCORE: 0.5935

HELIX: 0.8653

FCONS_SCORE: 1.1321

RIG_SCORE: 0.6871

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R511S	DO228929	LICA	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.7427
p.R518K	GP5d	large_intestine	COSMIC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.7237
p.E510Q	CAPAN-1	pancreas	COSMIC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.6744
p.T525A	SIDM01608	Endometrial Carcinoma	GDSC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.5833
p.T525A	ACH-000990	Endometrial/Uterine Cancer	CCLE	GRQSLMEMQ	DEG_APCC_DBOX_1	0.5833
p.E516Q	SIDM00934	Pancreatic Carcinoma	GDSC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.5633
p.E516Q	ACH-000354	Pancreatic Cancer	CCLE	GRQSLMEMQ	DEG_APCC_DBOX_1	0.5633
p.E516Q	CAPAN-1	pancreas	COSMIC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.5633
p.K501E	TCGA-IG-A5B8	ESCA	TCGA	GRQSLMEMQ	DEG_APCC_DBOX_1	0.5278
p.G509R	TCGA-BR-8060	STAD	TCGA	GRQSLMEMQ	DEG_APCC_DBOX_1	0.3056
p.G509R	DO38205	STAD	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.3056
p.R520C	TCGA-A5-A0G2	UCEC	TCGA	GRQSLMEMQ	DEG_APCC_DBOX_1	0.2778
p.R520C	DO41235	UCEC	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.2778
p.G522V	DO228971	LICA	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.2222
p.G522V	DO229041	LICA	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.2222
p.A523V	DO222737	COCA	ICGC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.1944
p.R524K	SIDM00537	Colorectal Carcinoma	GDSC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.1667
p.R524K	ACH-000982	Colon/Colorectal Cancer	CCLE	GRQSLMEMQ	DEG_APCC_DBOX_1	0.1667
p.R524K	ACH-001345	Colon/Colorectal Cancer	CCLE	GRQSLMEMQ	DEG_APCC_DBOX_1	0.1667
p.R524K	GP5d	large_intestine	COSMIC	GRQSLMEMQ	DEG_APCC_DBOX_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CV9	Optineurin	DEG_APCC_DBOX_1	510:518	GRQSLMEMQ	APC,CDC20,FZR1	0.687	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons