DegronMD - Q96D70(R3HDM4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K65R	TCGA-A5-A1OF	UCEC	TCGA	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.3056
p.R72H	TCGA-IB-7651	PAAD	TCGA	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.7133
p.Y57H	DO8858	COAD	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.0833
p.Y57H	SNU-175	large intestine	COSMIC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.0833
p.L68P	DO229010	COCA	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.7582
p.L68P	DO229005	COCA	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.7582
p.L68P	DO228947	LICA	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.7582
p.G67V	DO52018	LUSC	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.7532
p.P82Q	DO50278	SKCM	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.1111
p.Y78H	SIDM00216	Colorectal Carcinoma	GDSC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.2222
p.Y78H	ACH-000989	Colon/Colorectal Cancer	CCLE	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.2222
p.Y78H	SNU-175	large intestine	COSMIC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation rewiring degron network	0.2222
p.G67S	OAW-28	ovary	COSMIC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.6993
p.G67S	SW684	soft tissue	COSMIC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.6993
p.E72Q	LU-134-A	lung	COSMIC	GRKSLQRLE	DEG_APCC_DBOX_1	66:74	Mutation altering degron motif	0.6744

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons