DegronMD

Uniprot ID: Q96D70

Source protein: R3H domain-containing protein 4

Source gene: R3HDM4

Class: DEG_APCC_DBOX_1

Location: 66:74

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9416

ASA_SCORE: 98.0444

COIL: 0.6449

CONS_SCORE: 0.6845

DSS_SCORE: 0.4311

HELIX: 0.3016

FCONS_SCORE: 1.2152

RIG_SCORE: 0.7517

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K65R	TCGA-A5-A1OF	UCEC	TCGA	GRKSLQRLE	DEG_APCC_DBOX_1	0.3056
p.R72H	TCGA-IB-7651	PAAD	TCGA	GRKSLQRLE	DEG_APCC_DBOX_1	0.7133
p.Y57H	DO8858	COAD	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	0.0833
p.Y57H	SNU-175	large_intestine	COSMIC	GRKSLQRLE	DEG_APCC_DBOX_1	0.0833
p.L68P	DO229010	COCA	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	0.7582
p.L68P	DO229005	COCA	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	0.7582
p.L68P	DO228947	LICA	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	0.7582
p.G67V	DO52018	LUSC	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	0.7532
p.P82Q	DO50278	SKCM	ICGC	GRKSLQRLE	DEG_APCC_DBOX_1	0.1111
p.Y78H	SIDM00216	Colorectal Carcinoma	GDSC	GRKSLQRLE	DEG_APCC_DBOX_1	0.2222
p.Y78H	ACH-000989	Colon/Colorectal Cancer	CCLE	GRKSLQRLE	DEG_APCC_DBOX_1	0.2222
p.Y78H	SNU-175	large_intestine	COSMIC	GRKSLQRLE	DEG_APCC_DBOX_1	0.2222
p.G67S	OAW-28	ovary	COSMIC	GRKSLQRLE	DEG_APCC_DBOX_1	0.6993
p.G67S	SW684	soft_tissue	COSMIC	GRKSLQRLE	DEG_APCC_DBOX_1	0.6993
p.E72Q	LU-134-A	lung	COSMIC	GRKSLQRLE	DEG_APCC_DBOX_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96D70	R3H domain-containing protein 4	DEG_APCC_DBOX_1	66:74	GRKSLQRLE	APC,CDC20,FZR1	0.9416	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons