DegronMD - Q96DR7(ARHGEF26)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G177D	TCGA-2W-A8YY	CESC	TCGA	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.2222
p.G177D	DO223732	CESC	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.2222
p.P153S	TCGA-30-1718	OV	TCGA	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.0556
p.P153S	DO32708	OV	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.0556
p.P153S	SIDM00150	Colorectal Carcinoma	GDSC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.0556
p.P153S	ACH-000969	Colon/Colorectal Cancer	CCLE	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.0556
p.A154T	TCGA-AA-3492	COAD	TCGA	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.0833
p.A154T	DO8224	COAD	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.0833
p.A179V	TCGA-EJ-AB20	PRAD	TCGA	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1667
p.A179V	DO51335	PRAD	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1667
p.A154S	TCGA-EO-A22R	UCEC	TCGA	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.0833
p.A154S	DO42713	UCEC	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.0833
p.P158L	TCGA-F4-6856	COAD	TCGA	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1944
p.P158L	DO9114	COAD	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1944
p.P155S	TCGA-FR-A7U9	SKCM	TCGA	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1111
p.P155S	DO48546	SKCM	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1111
p.P155L	TCGA-FR-A7U9	SKCM	TCGA	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1111
p.P155L	DO48546	SKCM	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1111
p.P155L	SIDM01102	Non-Cancerous	GDSC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1111
p.P155L	ACH-002316	Non-Cancerous	CCLE	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1111
p.P155L	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1111
p.S172L	TCGA-SY-A9G5	BLCA	TCGA	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation altering degron motif	0.7667
p.S172L	DO51906	BLCA	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation altering degron motif	0.7667
p.S172L	DO222709	COCA	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation altering degron motif	0.7667
p.A180T	DO228338	MALY	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1389
p.A180T	SIDM00596	Endometrial Carcinoma	GDSC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1389
p.A180T	SIDM00948	Burkitt's Lymphoma	GDSC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1389
p.A180T	ACH-001517	Endometrial/Uterine Cancer	CCLE	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1389
p.A180T	ACH-002232	Lymphoma	CCLE	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1389
p.A180T	HEC-1	endometrium	COSMIC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1389
p.A180T	DG-75	haematopoietic and lymphoid tissue	COSMIC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.1389
p.T174N	DO49168	PACA	ICGC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.3056
p.D183H	SIDM00257	Neuroblastoma	GDSC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation rewiring degron network	0.0556
p.P173S	SIDM01612	Endometrial Carcinoma	GDSC	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation altering degron motif	0.6752
p.P173S	ACH-000946	Endometrial/Uterine Cancer	CCLE	TGLTASPVPSP	DEG_COP1_1	163:173	Mutation altering degron motif	0.6752

Kaplan plot for ARHGEF26 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF26

UniProt ID: Q96DR7

Entrez ID: 26084

Protein name: Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF26 in