DegronMD

Uniprot ID: Q96DR7

Source protein: Rho guanine nucleotide exchange factor 26

Source gene: ARHGEF26

Class: DEG_COP1_1

Location: 163:173

E3 ligase: COP1

DEGRON score: 0.9596

ASA_SCORE: 79.1

COIL: 0.9294

CONS_SCORE: 0.2979

DSS_SCORE: 0.715

HELIX: 0.0493

FCONS_SCORE: 0.9506

RIG_SCORE: 0.6422

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G177D	TCGA-2W-A8YY	CESC	TCGA	TGLTASPVPSP	DEG_COP1_1	0.2222
p.G177D	DO223732	CESC	ICGC	TGLTASPVPSP	DEG_COP1_1	0.2222
p.P153S	TCGA-30-1718	OV	TCGA	TGLTASPVPSP	DEG_COP1_1	0.0556
p.P153S	DO32708	OV	ICGC	TGLTASPVPSP	DEG_COP1_1	0.0556
p.P153S	SIDM00150	Colorectal Carcinoma	GDSC	TGLTASPVPSP	DEG_COP1_1	0.0556
p.P153S	ACH-000969	Colon/Colorectal Cancer	CCLE	TGLTASPVPSP	DEG_COP1_1	0.0556
p.A154T	TCGA-AA-3492	COAD	TCGA	TGLTASPVPSP	DEG_COP1_1	0.0833
p.A154T	DO8224	COAD	ICGC	TGLTASPVPSP	DEG_COP1_1	0.0833
p.A179V	TCGA-EJ-AB20	PRAD	TCGA	TGLTASPVPSP	DEG_COP1_1	0.1667
p.A179V	DO51335	PRAD	ICGC	TGLTASPVPSP	DEG_COP1_1	0.1667
p.A154S	TCGA-EO-A22R	UCEC	TCGA	TGLTASPVPSP	DEG_COP1_1	0.0833
p.A154S	DO42713	UCEC	ICGC	TGLTASPVPSP	DEG_COP1_1	0.0833
p.P158L	TCGA-F4-6856	COAD	TCGA	TGLTASPVPSP	DEG_COP1_1	0.1944
p.P158L	DO9114	COAD	ICGC	TGLTASPVPSP	DEG_COP1_1	0.1944
p.P155S	TCGA-FR-A7U9	SKCM	TCGA	TGLTASPVPSP	DEG_COP1_1	0.1111
p.P155S	DO48546	SKCM	ICGC	TGLTASPVPSP	DEG_COP1_1	0.1111
p.P155L	TCGA-FR-A7U9	SKCM	TCGA	TGLTASPVPSP	DEG_COP1_1	0.1111
p.P155L	DO48546	SKCM	ICGC	TGLTASPVPSP	DEG_COP1_1	0.1111
p.P155L	SIDM01102	Non-Cancerous	GDSC	TGLTASPVPSP	DEG_COP1_1	0.1111
p.P155L	ACH-002316	Non-Cancerous	CCLE	TGLTASPVPSP	DEG_COP1_1	0.1111
p.P155L	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	TGLTASPVPSP	DEG_COP1_1	0.1111
p.S172L	TCGA-SY-A9G5	BLCA	TCGA	TGLTASPVPSP	DEG_COP1_1	0.7667
p.S172L	DO51906	BLCA	ICGC	TGLTASPVPSP	DEG_COP1_1	0.7667
p.S172L	DO222709	COCA	ICGC	TGLTASPVPSP	DEG_COP1_1	0.7667
p.A180T	DO228338	MALY	ICGC	TGLTASPVPSP	DEG_COP1_1	0.1389
p.A180T	SIDM00596	Endometrial Carcinoma	GDSC	TGLTASPVPSP	DEG_COP1_1	0.1389
p.A180T	SIDM00948	Burkitt's Lymphoma	GDSC	TGLTASPVPSP	DEG_COP1_1	0.1389
p.A180T	ACH-001517	Endometrial/Uterine Cancer	CCLE	TGLTASPVPSP	DEG_COP1_1	0.1389
p.A180T	ACH-002232	Lymphoma	CCLE	TGLTASPVPSP	DEG_COP1_1	0.1389
p.A180T	HEC-1	endometrium	COSMIC	TGLTASPVPSP	DEG_COP1_1	0.1389
p.A180T	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	TGLTASPVPSP	DEG_COP1_1	0.1389
p.T174N	DO49168	PACA	ICGC	TGLTASPVPSP	DEG_COP1_1	0.3056
p.D183H	SIDM00257	Neuroblastoma	GDSC	TGLTASPVPSP	DEG_COP1_1	0.0556
p.P173S	SIDM01612	Endometrial Carcinoma	GDSC	TGLTASPVPSP	DEG_COP1_1	0.6752
p.P173S	ACH-000946	Endometrial/Uterine Cancer	CCLE	TGLTASPVPSP	DEG_COP1_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TGLTASPVPSP

Degron related mutations and impact score

Drug responses associated with ARHGEF26 mutations

All proteins holding degron of TGLTASPVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DR7	Rho guanine nucleotide exchange factor 26	DEG_COP1_1	163:173	TGLTASPVPSP	COP1	0.9596	More...