DegronMD - Q96DZ1(ERLEC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L103I	TCGA-HU-A4H3	STAD	TCGA	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6063
p.L103I	DO47903	STAD	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6063
p.S114F	TCGA-W3-AA1V	SKCM	TCGA	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1667
p.S114F	DO51276	SKCM	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1667
p.E102D	DO229018	LICA	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.5647
p.G97V	DO229026	LICA	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.C113F	DO229037	LICA	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1944
p.C113F	DO229045	LICA	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1944
p.K93R	DO229232	THCA	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation blocking ubiquitination signal	0.5833
p.S111G	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.S111G	SIDM00060	Ovarian Carcinoma	GDSC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.S111G	SIDM00357	Small Cell Lung Carcinoma	GDSC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.S111G	SIDM00165	Other Solid Cancers	GDSC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.I117V	SIDM01191	Osteosarcoma	GDSC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0833
p.I117V	U-2-OS	bone	COSMIC	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0833
p.E92Q	ACH-001864	Bile Duct Cancer	CCLE	PRELLEPLF	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111

Kaplan plot for ERLEC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERLEC1

UniProt ID: Q96DZ1

Entrez ID: 27248

Protein name: Endoplasmic reticulum lectin 1 (ER lectin) (Erlectin) (XTP3-transactivated gene B protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERLEC1 in