DegronMD

Uniprot ID: Q96DZ1

Source protein: Endoplasmic reticulum lectin 1

Source gene: ERLEC1

Class: DEG_APCC_DBOX_1

Location: 100:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9655

ASA_SCORE: 48.7111

COIL: 0.1032

CONS_SCORE: 0.6008

DSS_SCORE: 0.4012

HELIX: 0.8884

FCONS_SCORE: 1.0011

RIG_SCORE: 0.8091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L103I	TCGA-HU-A4H3	STAD	TCGA	PRELLEPLF	DEG_APCC_DBOX_1	0.6063
p.L103I	DO47903	STAD	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	0.6063
p.S114F	TCGA-W3-AA1V	SKCM	TCGA	PRELLEPLF	DEG_APCC_DBOX_1	0.1667
p.S114F	DO51276	SKCM	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	0.1667
p.E102D	DO229018	LICA	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	0.5647
p.G97V	DO229026	LICA	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	0.25
p.C113F	DO229037	LICA	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	0.1944
p.C113F	DO229045	LICA	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	0.1944
p.K93R	DO229232	THCA	ICGC	PRELLEPLF	DEG_APCC_DBOX_1	0.5833
p.S111G	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PRELLEPLF	DEG_APCC_DBOX_1	0.25
p.S111G	SIDM00060	Ovarian Carcinoma	GDSC	PRELLEPLF	DEG_APCC_DBOX_1	0.25
p.S111G	SIDM00357	Small Cell Lung Carcinoma	GDSC	PRELLEPLF	DEG_APCC_DBOX_1	0.25
p.S111G	SIDM00165	Other Solid Cancers	GDSC	PRELLEPLF	DEG_APCC_DBOX_1	0.25
p.I117V	SIDM01191	Osteosarcoma	GDSC	PRELLEPLF	DEG_APCC_DBOX_1	0.0833
p.I117V	U-2-OS	bone	COSMIC	PRELLEPLF	DEG_APCC_DBOX_1	0.0833
p.E92Q	ACH-001864	Bile Duct Cancer	CCLE	PRELLEPLF	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DZ1	Endoplasmic reticulum lectin 1	DEG_APCC_DBOX_1	100:108	PRELLEPLF	APC,CDC20,FZR1	0.9655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons