DegronMD - Q96E40(SPACA9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A153T	SIDM01314	Colorectal Carcinoma	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1667
p.A153T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1667
p.A153T	NCI-H1155	lung	COSMIC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.1667
p.P159S	SIDM00216	Colorectal Carcinoma	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.5641
p.P159S	SNU-175	large intestine	COSMIC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.5641
p.P159L	SIDM01176	B-Lymphoblastic Leukemia	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.6471
p.P159L	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.6471
p.A171V	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.2222
p.A171V	NCI-H2009	lung	COSMIC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation rewiring degron network	0.2222
p.R160H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8244
p.R160H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PRKVLQHVS	DEG_APCC_DBOX_1	159:167	Mutation altering degron motif	0.8244

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons