DegronMD

Uniprot ID: Q96E40

Source protein: Sperm acrosome-associated protein 9

Source gene: SPACA9

Class: DEG_APCC_DBOX_1

Location: 159:167

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9278

ASA_SCORE: 82.9778

COIL: 0.6789

CONS_SCORE: 0.4907

DSS_SCORE: 0.4845

HELIX: 0.2631

FCONS_SCORE: 1.1154

RIG_SCORE: 0.7245

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A153T	SIDM01314	Colorectal Carcinoma	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	0.1667
p.A153T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	0.1667
p.A153T	NCI-H1155	lung	COSMIC	PRKVLQHVS	DEG_APCC_DBOX_1	0.1667
p.P159S	SIDM00216	Colorectal Carcinoma	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	0.5641
p.P159S	SNU-175	large_intestine	COSMIC	PRKVLQHVS	DEG_APCC_DBOX_1	0.5641
p.P159L	SIDM01176	B-Lymphoblastic Leukemia	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	0.6471
p.P159L	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	PRKVLQHVS	DEG_APCC_DBOX_1	0.6471
p.A171V	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	0.2222
p.A171V	NCI-H2009	lung	COSMIC	PRKVLQHVS	DEG_APCC_DBOX_1	0.2222
p.R160H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRKVLQHVS	DEG_APCC_DBOX_1	0.8244
p.R160H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PRKVLQHVS	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96E40	Sperm acrosome-associated protein 9	DEG_APCC_DBOX_1	159:167	PRKVLQHVS	APC,CDC20,FZR1	0.9278	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons